{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:41:53Z","timestamp":1791956513344,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Society of Pediatric Dermatology Pilot Project grant."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>Background\/Objective<\/jats:title>The isothiazolinones methylchloroisothiazolinone (MCI<\/jats:styled-content>) and methylisothiazolinone (MI<\/jats:styled-content>) are prevalent pediatric contact sensitizers. MI<\/jats:styled-content> allergic contact dermatitis (ACD<\/jats:styled-content>) is underreported in the literature. The objective of the current study was to use a database of provider\u2010reported U.S. pediatric patch test cases to evaluate the positive patch test (PPT<\/jats:styled-content>) prevalence rates of the combined preservative test substrate MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and of MI<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>Methods<\/jats:title>U.S. pediatric patch test providers in all 50 states who had joined the registry were invited to submit deidentified cases to the database. More than 1100 logged cases in the database were evaluated for PPT<\/jats:styled-content>s to MCI<\/jats:styled-content>\/MI<\/jats:styled-content> combination, MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and MI<\/jats:styled-content>, and MI<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>Results<\/jats:title>Within 1 year of data collection, 96 cases with a PPT<\/jats:styled-content> for MCI<\/jats:styled-content>\/MI<\/jats:styled-content>, MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and MI<\/jats:styled-content>, and MI<\/jats:styled-content> alone were identified; 37 of these were positive to MCI<\/jats:styled-content>\/MI<\/jats:styled-content>, with MI<\/jats:styled-content> alone not tested or negative, and 39 were positive to MI<\/jats:styled-content> only, with MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and MI<\/jats:styled-content> tested. Fifteen (41%) of the MCI<\/jats:styled-content>\/MI<\/jats:styled-content> cases were detected using an epicutaneous patch test alone and 22 cases (59%) using comprehensive patch testing. Only one case (3%) of MI<\/jats:styled-content> alone sensitization was detected using T.R.U.E.<\/jats:styled-content> plus a supplemental panel of tests; the remaining 38 cases (97%) were detected using comprehensive testing. Testing with only the combined MCI<\/jats:styled-content>\/MI<\/jats:styled-content> preservative substrate may miss 51% of MI<\/jats:styled-content> allergies.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Appropriate testing of isothiazolinones is needed to clarify the true prevalence of sensitization to these allergens and the burden of pediatric ACD<\/jats:styled-content>. Patch testing for MI<\/jats:styled-content> alone in addition to MCI<\/jats:styled-content>\/MI<\/jats:styled-content> combination is warranted in children with recalcitrant dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13063","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T09:03:02Z","timestamp":1485162182000},"page":"138-143","source":"Crossref","is-referenced-by-count":11,"title":["Appropriate Testing of Isothiazolinones in Children"],"prefix":"10.1111","volume":"34","author":[{"given":"Alina","family":"Goldenberg","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California at San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lipp","sequence":"additional","affiliation":[{"name":"Lake Erie Consortium for Osteopathic Medical Training (LECOMT)\/Larkin Community Hospital\u2010Palm Springs Campus Hialeah Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Dermatology Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"JacobSB BantaMR.Focus on T.R.U.E. Test Allergen #17 Methylchloroisothiazolinone\/Methylisothiazolinone. Dermatologist.http:\/\/www.the-dermatologist.com\/article\/5879(accessed December 3 2016)."},{"key":"e_1_2_7_3_1","unstructured":"GadberryR.Ingredient Review: The Safety of Paraben Substitutes. Skin Inc. magazine.http:\/\/www.skininc.com\/skinscience\/ingredients\/17013151.html(accessed December 3 2016)."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91318-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12560"},{"key":"e_1_2_7_6_1","unstructured":"Dow Chemical Company.Preservatives for Household and Industrial Use: Highly Effective and Environmentally Sound Microbicides.http:\/\/www.dow.com\/microbial\/applications\/ma_rinseoff_app.htm(accessed December 3 2016)."},{"key":"e_1_2_7_7_1","unstructured":"Dow Chemical Company.NEOLONE\u2122 for Personal Care: Preservatives for Skin Sun and Hair Care Products.http:\/\/www.dow.com\/microbial\/applications\/ma_rinseoff_app.htm(accessed December 3 2016)."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000152"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/132564"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.e3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000061"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000083"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2011.11011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1453"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12328"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000119"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000214"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2310\/6620.2008.08057","article-title":"Patch testing: the whole in addition to the sum of its parts is greatest","volume":"20","author":"Nijhawan RI","year":"2009","journal-title":"Dermatitis"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04277.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00398.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31827edc73"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:30:14Z","timestamp":1696023014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/pde.13063"],"URL":"https:\/\/doi.org\/10.1111\/pde.13063","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}