{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:13:49Z","timestamp":1775636029101,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent data have shown an increasing occurrence of atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) in children and adolescents, as well as in adults. Most of the epidemiologic research on <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> is limited to pediatric and youth populations and is based on self\u2010reported questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide, population\u2010based, cross\u2010sectional retrospective study of adolescents with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was performed to estimate its prevalence, trends, and association with demographic factors and comorbidities. The study included all Israeli teens going through medical evaluation as part of the assessment before being conscripted into the military from 1998 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,187,757 adolescents were included in the study population, with an overall prevalence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> of 0.64% in boys and 0.9% in girls. Over the study period, the prevalence of AD steadily increased, especially in the mild disease group. A greater risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was found in subjects with high predicted socioeconomic status (male: odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.14 [95% confidence interval {<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>} 1.11, 1.16]; female: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.08, [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05, 1.10]) and Israeli\u2010born subjects (male: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.34 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.21, 1.48]; female: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.12 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.01, 1.23]). Allergic conditions such as asthma, conjunctivitis, and contact dermatitis were more prevalent in subjects with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. There was a significantly higher prevalence of migraine in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (male: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.35 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.18, 1.54]; female: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.51 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.30, 1.74]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large cross\u2010sectional study demonstrates the increasing prevalence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in adolescents and its relation to other allergic diseases and migraine. It is hoped that greater awareness of the distinctive epidemiologic characteristics of this population will lead to better recognition and management of the disease and its comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13084","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T05:52:38Z","timestamp":1489989158000},"page":"247-252","source":"Crossref","is-referenced-by-count":21,"title":["Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine"],"prefix":"10.1111","volume":"34","author":[{"given":"Rony","family":"Shreberk\u2010Hassidim","sequence":"first","affiliation":[{"name":"Department of Dermatology Hadassah\u2014Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayal","family":"Hassidim","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Hadassah\u2014Hebrew University Medical Center Jerusalem Israel"},{"name":"Israeli Defense Force Medical Corps Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Gronovich","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Dalal","sequence":"additional","affiliation":[{"name":"Israeli Defense Force Medical Corps Ramat Gan Israel"},{"name":"Department of Dermatology Rabin Medical Center Beilinson Hospital Petah Tiqva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vered","family":"Molho\u2010Pessach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah\u2014Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Zlotogorski","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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