{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:42:40Z","timestamp":1761896560055,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>The use of collagenase for enzymatic wound debridement has been studied extensively and has been established as the standard of care for nonhealing and necrotic wounds in individuals for whom surgical intervention is not an option. Collagenase has been shown to be effective in adults but has been studied in a limited capacity in infants and neonates. The purpose of this study was to investigate the use of collagenase in the neonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of infants and neonates admitted to the <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> at Arkansas Children's Hospital with nonhealing wounds for which collagenase was used for wound healing over a 1\u2010year time period. Six wounds were identified: five surgical wound dehiscence and one intravenous infiltrate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before the use of collagenase, five of the six wounds had been treated with an alternative dressing. Once collagenase was initiated, three of these wounds reached complete granulation and closure in less time than in the episode of prior therapy. The number of days to reach 100% granulation once treated with collagenase was 5 to 18\u00a0days (mean 12.2\u00a0days). Surgical intervention for the debridement and closure of these wounds was not required, providing cost savings to the patient. Daily wound care was completed with negligible pain recordings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of collagenase for enzymatic debridement can be beneficial, safe, and effective for the treatment of nonhealing and necrotic wounds in infants and neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13118","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T07:41:27Z","timestamp":1495179687000},"page":"277-281","source":"Crossref","is-referenced-by-count":5,"title":["Collagenase for Wound Debridement in the Neonatal Intensive Care Unit: A Retrospective Case Series"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-8960","authenticated-orcid":false,"given":"Elizabeth","family":"Huett","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Arkansas Children's Hospital Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney","family":"Bartley","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Arkansas Children's Hospital Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darla","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Arkansas Children's Hospital Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Della","family":"Reasbeck","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Arkansas Children's Hospital Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"McKitrick\u2010Bandy","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Arkansas Children's Hospital Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Arkansas Children's Hospital Little Rock Arkansas"},{"name":"Department of Physical Therapy University of Central Arkansas Conway Arkansas"},{"name":"Center for Translational Neuroscience University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"volume-title":"Wound care: a collaborative practice manual for health professionals","year":"2012","author":"Sussman C","key":"e_1_2_6_2_1"},{"volume-title":"Wound healing: evidence\u2010based management","year":"2010","author":"McCulloch J","key":"e_1_2_6_3_1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e3181bfdd1a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e3181bfdf83"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.11.s2.1.x"},{"key":"e_1_2_6_7_1","first-page":"81","article-title":"Outcomes of 4 methods of debridement using a decision analysis methodology","volume":"12","author":"Mosher BA","year":"1999","journal-title":"Adv Wound Care"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.807268"},{"key":"e_1_2_6_9_1","unstructured":"Smith & Nephew.Collagenase Santyl: application process. Available at:http:\/\/www.santyl.com\/hcp\/application(accessed November 11 2015)."},{"key":"e_1_2_6_10_1","first-page":"270","article-title":"A comparison of collagenase to hydrogel dressings in wound debridement","volume":"22","author":"Milne CT","year":"2010","journal-title":"Wounds"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(02)00191-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.00119.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00375.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01546.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.154"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01773.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:56:52Z","timestamp":1696211812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/pde.13118"],"URL":"https:\/\/doi.org\/10.1111\/pde.13118","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}