{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:16:13Z","timestamp":1784380573977,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002077","name":"Epidermolysis Bullosa Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bullous dermolysis of the newborn (<jats:styled-content style=\"fixed-case\">BDN<\/jats:styled-content>) is a subtype of dystrophic epidermolysis bullosa (<jats:styled-content style=\"fixed-case\">DEB<\/jats:styled-content>) characterized by skin fragility and blister formation at birth that typically resolves within the first year of life. Abnormal intraepidermal retention of type <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> collagen (C7) has been reported as a characteristic feature of <jats:styled-content style=\"fixed-case\">BDN<\/jats:styled-content>, but few studies have investigated the specificity of this finding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed pathology reports of patients diagnosed with <jats:styled-content style=\"fixed-case\">DEB<\/jats:styled-content> using immunofluorescence mapping from January 2001 to January 2015. For cases describing intraepidermal accumulation of C7, we collected information on patient characteristics, including genetic testing results, clinical outcome, and concurrent electron microscopy findings, where available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 143 cases of <jats:styled-content style=\"fixed-case\">DEB<\/jats:styled-content> with immunofluorescence mapping, eight patients had intracytoplasmic epidermal retention of C7. Of these eight patients, two were lost to follow\u2010up, four had complete resolution of bullae, and two had marked improvement with rare residual bullae. Concurrent electron microscopic findings available for three patients were consistent with <jats:styled-content style=\"fixed-case\">BDN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our review of immunofluorescence mapping findings in patients with <jats:styled-content style=\"fixed-case\">DEB<\/jats:styled-content> found that 5.6% had abnormal intracytoplasmic epidermal retention of C7, a finding previously reported in <jats:styled-content style=\"fixed-case\">BDN<\/jats:styled-content>. All such patients with clinical outcomes available had resolution or marked improvement of bullae, consistent with clinical outcomes expected in <jats:styled-content style=\"fixed-case\">BDN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13132","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T07:41:27Z","timestamp":1495179687000},"page":"308-314","source":"Crossref","is-referenced-by-count":8,"title":["Intraepidermal Type <scp>VII<\/scp> Collagen by Immunofluorescence Mapping: A Specific Finding for Bullous Dermolysis of the Newborn"],"prefix":"10.1111","volume":"34","author":[{"given":"Gillian","family":"Heinecke","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Peter","family":"Marinkovich","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Stanford California"},{"name":"Dermatology Service Veterans Affairs Palo Alto Medical Center Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-2471","authenticated-orcid":false,"given":"Kerri E.","family":"Rieger","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Stanford California"},{"name":"Department of Pathology School of Medicine Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660110077020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12704"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12513"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70021-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12364899"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06873.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00447.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00649.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874614"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.07.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01880.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.12.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00394.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12230"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.045302"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13190"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:57:08Z","timestamp":1696211828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/pde.13132"],"URL":"https:\/\/doi.org\/10.1111\/pde.13132","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}