{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:30:21Z","timestamp":1746145821451,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T00:00:00Z","timestamp":1527292800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1T32AR059038\u201001A1"],"award-info":[{"award-number":["1T32AR059038\u201001A1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Infantile hemangiomas (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s) are vascular tumors with the potential for significant morbidity. There is a lack of validated objective tools to assess <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> severity and response to treatment. Diffuse optical spectroscopy (<jats:styled-content style=\"fixed-case\">DOS<\/jats:styled-content>), a noninvasive, nonionizing imaging modality, can measure total hemoglobin concentration and hemoglobin oxygen saturation in tissue to assess <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> vascularity and response to treatment. Our objective was to evaluate the utility of a wireless, handheld <jats:styled-content style=\"fixed-case\">DOS<\/jats:styled-content> system to assess <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> characteristics at selected points during their clinical course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen subjects (initial age 5.8 \u00b1 2.0 mos) with 15 <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s were enrolled. <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s were classified as proliferative, plateau phase, or involuting. Nine patients with 11 <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s were untreated; four patients with 4 <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s were treated with timolol or propranolol. Each <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> was evaluated by placing the <jats:styled-content style=\"fixed-case\">DOS<\/jats:styled-content> system directly on the lesion as well a normal contralateral skin site. <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> vascularity and oxygenation were scored using a newly defined normalized hypoxia fraction (<jats:styled-content style=\"fixed-case\">NHF<\/jats:styled-content>) coefficient. Measurements were recorded at various intervals from the initial visit to 1 to 2 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the nine untreated <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s, the <jats:styled-content style=\"fixed-case\">NHF<\/jats:styled-content> was highest at 6 months of age, during proliferation. Differences in <jats:styled-content style=\"fixed-case\">NHF<\/jats:styled-content>s between the proliferation and the plateau (p = 0.02) and involuting (p &lt; 0.001) stages were statistically significant. In treated patients, the <jats:styled-content style=\"fixed-case\">NHF<\/jats:styled-content> normalized to 60% after 2 months. One treated <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> came within 5% of the <jats:styled-content style=\"fixed-case\">NHF<\/jats:styled-content> for normal skin after 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DOS<\/jats:styled-content> can be used to assess the vascularity and tissue oxygenation of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s and monitor their progression and response to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13150","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T10:26:45Z","timestamp":1495794405000},"page":"386-391","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of Infantile Hemangiomas Using a Handheld Wireless Diffuse Optical Spectroscopic Device"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-2269","authenticated-orcid":false,"given":"Christopher J.","family":"Fong","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Columbia University New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Garzon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Medical Center New York City New York"},{"name":"Department of Pediatrics Columbia University Medical Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer W.","family":"Hoi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Columbia University Medical Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine T.","family":"Lauren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Medical Center New York City New York"},{"name":"Department of Pediatrics Columbia University Medical Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Medical Center New York City New York"},{"name":"Department of Pediatrics Columbia University Medical Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Geller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mount Sinai Hospital New York City New York"},{"name":"Department of Dermatology Mount Sinai Hospital New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Antonov","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Medical Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Weitz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Medical Center New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery Columbia University New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas H.","family":"Hielscher","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University New York City New York"},{"name":"Department of Radiology Columbia University Medical Center New York City New York"},{"name":"Department of 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