{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:03:01Z","timestamp":1782345781998,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Benign cephalic histiocytosis (<jats:styled-content style=\"fixed-case\">BCH<\/jats:styled-content>) is a rare form of non\u2010Langerhans cell histiocytosis in infants and young children characterized by self\u2010healing macules and papules occurring primarily in the head and neck region. So far there have been nearly 60 reported cases in the English\u2010language literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we evaluated clinical features and follow\u2010up data of 11 patients diagnosed with <jats:styled-content style=\"fixed-case\">BCH<\/jats:styled-content> between 2004 and 2016 in the Department of Dermatovenereology, Istanbul Medical Faculty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 5 girls and 6 boys (median age 24 months, range 9\u201372 months). The median age at the onset of lesions was 8 months (range 3\u201336 months). The lesions first appeared on the face in 10 patients and on the trunk in 1. Proximal parts of the extremities and trunk were also involved in nine patients (81.8%). Patients were categorized into two groups based on their clinical features; five had 20 to 30 predominantly red\u2010brown dome\u2010shaped papules and six had 50 to hundreds of yellow\u2010brown or predominantly pinkish brown flat papules. Four patients were lost to follow\u2010up. In seven patients with a mean follow\u2010up of 5 years, four had nearly complete resolution and three showed remarkable regression without treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With 11 additional cases from a single center, <jats:styled-content style=\"fixed-case\">BCH<\/jats:styled-content> seems to be an underrecognized disease. Its clinical presentation is not uniform. Considering that most of the patients in this series and those previously reported had extracephalic involvement, the term \u201ccephalic\u201d needs to be reevaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13153","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T08:28:46Z","timestamp":1493800126000},"page":"392-397","source":"Crossref","is-referenced-by-count":25,"title":["Novel Clinical Observations on Benign Cephalic Histiocytosis in a Large Series"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-8402","authenticated-orcid":false,"given":"Alg\u00fcn","family":"Polat Ekinci","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesimi","family":"Buyukbabani","sequence":"additional","affiliation":[{"name":"Department of Pathology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Baykal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660210088025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12135"},{"key":"e_1_2_5_4_1","first-page":"232","article-title":"Singular, \u201cinfantile histiocytosis with cells with intracytoplasmic vermiform particles.\u201d","volume":"78","author":"Gianotti F","year":"1971","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"key":"e_1_2_5_5_1","first-page":"15","article-title":"Benign cephalic histiocytosis","volume":"95","author":"Lange M","year":"2015","journal-title":"Cutis"},{"key":"e_1_2_5_6_1","first-page":"941","article-title":"Benign cephalic histiocytosis","volume":"51","author":"Bandyopadhyay D","year":"2014","journal-title":"Indian Pediatr"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.120646"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124602"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.05861.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00721.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70247-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70259-V"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02712.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200002000-00014"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70228-X"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22109.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199308000-00004"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01779.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00187.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:05:36Z","timestamp":1696161936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/pde.13153"],"URL":"https:\/\/doi.org\/10.1111\/pde.13153","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}