{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:53:08Z","timestamp":1768647188229,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,30]],"date-time":"2017-07-30T00:00:00Z","timestamp":1501372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acanthosis nigricans (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) is the most common cutaneous manifestation of insulin resistance (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) and is commonly seen in non\u2010Caucasian populations. Variable benefits of metformin in the treatment of <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> have been reported in the literature. We report an adolescent Caucasian boy with <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and extensive <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> who showed complete resolution of <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> after 2 years of metformin, despite persistence of <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pde.13206","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T04:36:39Z","timestamp":1501475799000},"source":"Crossref","is-referenced-by-count":12,"title":["Acanthosis Nigricans and Its Response to Metformin"],"prefix":"10.1111","volume":"34","author":[{"given":"Dinesh","family":"Giri","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology Alder Hey Children's National Health Service Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussain","family":"Alsaffar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Alder Hey Children's National Health Service Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renuka","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Alder Hey Children's National Health Service Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,30]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/edpract-2011-301426"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032010000200009"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/479354"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.137765"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1980.tb01003.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K446"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.4200"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00013.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345776"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:28:34Z","timestamp":1695572914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,30]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/pde.13206"],"URL":"https:\/\/doi.org\/10.1111\/pde.13206","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,30]]}}}