{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:37:32Z","timestamp":1774669052028,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> diagnosed between the ages of 6 and 11 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were treated with oral finasteride 1 to 5\u00a0mg\/day. All had entered puberty at the time of treatment initiation. All had normal laboratory results before starting treatment. The maximum duration of treatment was 24\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four patients were female. Two were overweight. Three had been previously treated with oral antibiotics, and two of these with oral isotretinoin, with partial or no improvement. Overall improvement of the disease was observed in all patients, with a reduction of the frequency and intensity of the flares. No adverse effects were observed or reported during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> can be challenging. The options available include antimicrobials, immunosuppressants, hormonal therapies, lasers, and surgery. The authors report the largest series of children with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> treated with finasteride. The results support the use of finasteride as monotherapy for the treatment of this disease in children. Further studies are necessary to fully understand the role of this drug in the management of this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13216","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:12:58Z","timestamp":1500624778000},"page":"578-583","source":"Crossref","is-referenced-by-count":28,"title":["Hidradenitis Suppurativa in Children Treated with Finasteride\u2014A Case Series"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3385-2552","authenticated-orcid":false,"given":"Fernando","family":"Mota","sequence":"first","affiliation":[{"name":"Department of Dermatology Centro Hospitalar do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centro Hospitalar do Porto Porto Portugal"},{"name":"Dermatology Research Unit Centro Hospitalar do Porto Porto Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Selores","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centro Hospitalar do Porto Porto Portugal"},{"name":"Dermatology Research Unit Centro Hospitalar do Porto Porto Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00876.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.1999.00077.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.007"},{"key":"e_1_2_5_5_1","first-page":"44","article-title":"Finasteride in hidradenitis suppurativa: a \u201cmale\u201d therapy for a predominantly \u201cfemale\u201d disease","volume":"9","author":"Khandalavala BN","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90321-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb03227.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"22373","DOI":"10.5070\/D3204022373","article-title":"An atlas of the morphologic manifestations of hidradenitis suppurativa","volume":"20","author":"Scheinfeld N","year":"2014","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04137.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630510031403"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2874"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-014-0091-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5070\/D35VW402NF"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:27:39Z","timestamp":1695572859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,20]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/pde.13216"],"URL":"https:\/\/doi.org\/10.1111\/pde.13216","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,20]]}}}