{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:33:21Z","timestamp":1768545201662,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Hypopigmented mycosis fungoides (HMF<\/jats:styled-content>) is the most common variant of mycosis fungoides (MF<\/jats:styled-content>) in children. Large\u2010cell transformation in HMF<\/jats:styled-content> has never been reported. Herein we report a case of HMF<\/jats:styled-content> in an 8\u2010year\u2010old boy who presented with a 6\u2010year history of hypopigmented patches on the bilateral arms, lower back, buttocks, posterior thighs, and lower legs. Biopsy revealed an abnormal CD<\/jats:styled-content>8+<\/jats:sup> epidermotropic T\u2010cell infiltrate consistent with the diagnosis of MF<\/jats:styled-content>. The T\u2010cell clonality study was positive. The patient was started on narrowband ultraviolet B (NBUVB) phototherapy and topical steroids. He had a 50% reduction in his patches after 10\u00a0months of treatment, after which he developed a single annular plaque on his left thigh. The biopsy specimen demonstrated large cells that were diffusely CD<\/jats:styled-content>8+<\/jats:sup> and CD<\/jats:styled-content>30\u2212<\/jats:sup>. Clobetasol propionate ointment was prescribed, which led to complete resolution of the plaque within 2\u00a0weeks. NBUVB phototherapy was continued and the patient had a complete response within the following 5\u00a0months. The case is an example of exceptionally rare large\u2010cell transformation in pediatric MF<\/jats:styled-content> and stresses the importance of regular follow\u2010up of these patients.<\/jats:p>","DOI":"10.1111\/pde.13233","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T06:22:34Z","timestamp":1502691754000},"source":"Crossref","is-referenced-by-count":5,"title":["Hypopigmented Mycosis Fungoides with Large Cell Transformation in a Child"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-1601","authenticated-orcid":false,"given":"Dinesh","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw J.","family":"Jedrych","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonhan","family":"Ho","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-5710","authenticated-orcid":false,"given":"Oleg E.","family":"Akilov","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Program Department of Dermatology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24639"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.049"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12217"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12338"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2009.08091"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310020530"},{"key":"e_1_2_4_8_1","first-page":"265","article-title":"Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study","volume":"132","author":"Salhany KE","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199206000-00002"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1150"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.11.010"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.7142"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12352"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12458"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5259-8"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:27:52Z","timestamp":1695572872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/pde.13233"],"URL":"https:\/\/doi.org\/10.1111\/pde.13233","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,14]]}}}