{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:09:09Z","timestamp":1776960549628,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 5\u2010year\u2010old girl with T\u2010cell acute lymphoblastic leukemia (T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) developed a progressive eruption of crusted papules and ulcerative plaques involving 80% of her body surface area with histopathology consistent with febrile ulceronecrotic Mucha\u2013Habermann disease (<jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content>), although multiple specimens also contained clonal leukemic cells. Her skin disease was refractory to many classic treatments for <jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content>, including methotrexate, and became so severe that concern about superinfection prevented intensification of chemotherapy for her malignancy. The addition of basiliximab promoted gradual improvement of the skin, allowing for chemotherapy intensification and subsequent bone marrow transplantation, after which the eruption resolved completely. This report describes a severe case of <jats:styled-content style=\"fixed-case\">FUMHD<\/jats:styled-content>\u2010like eruption associated with clonal leukemic cells that improved with basiliximab, suggesting anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 therapy as a novel treatment for ulceronecrotic skin disease in the setting of high interleukin\u20102 levels.<\/jats:p>","DOI":"10.1111\/pde.13235","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T11:20:49Z","timestamp":1504869649000},"source":"Crossref","is-referenced-by-count":7,"title":["Severe Mucha\u2013Habermann\u2010Like Ulceronecrotic Skin Disease in T\u2010Cell Acute Lymphoblastic Leukemia Responsive to Basiliximab and Stem Cell Transplant"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-2854","authenticated-orcid":false,"given":"Lauren A.V.","family":"Orenstein","sequence":"first","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-1725","authenticated-orcid":false,"given":"Carrie. C.","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine School of Medicine Washington University in St. Louis St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea T.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinodh","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7179-5168","authenticated-orcid":false,"given":"Markus D.","family":"Boos","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Seattle Children's Hospital Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald B.","family":"Wertheim","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Treat","sequence":"additional","affiliation":[{"name":"Section\u00a0of Pediatric Dermatology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Teachey","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346245"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25470"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08236.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.06.009"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2155"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-013-0054-x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1791"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2016.03.002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01531.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg014"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04353.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.376"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12373"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:28:02Z","timestamp":1695572882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/pde.13235"],"URL":"https:\/\/doi.org\/10.1111\/pde.13235","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}