{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:59:24Z","timestamp":1790179164103,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Interferon gamma (IFN\u2010\u03b3) has been used treat severe atopic dermatitis, with equivocal results. Recurrent eczema herpeticum is an underappreciated, therapeutically challenging complication of severe atopic dermatitis. Defects in IFN\u2010\u03b3 and other cytokine pathways have been identified in individuals with confirmed eczema herpeticum. This suggests possible benefit from IFN\u2010\u03b3 treatment for confirmed eczema herpeticum. The objective of the current study was to evaluate immunologic and microbial parameters and response to IFN\u2010\u03b3 treatment in children with confirmed eczema herpeticum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of medical records from eight children with confirmed eczema herpeticum and two children with severe atopic dermatitis without a history of eczema herpeticum treated with subcutaneous IFN\u2010\u03b3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our cohort of children with confirmed eczema herpeticum was predominantly male and had high total serum immunoglobulin E, evidence of insufficient toll\u2010like receptor responses, and streptococcal skin and pharyngeal colonization. The duration of IFN\u2010\u03b3 administration was 4.5\u201025\u00a0months. Five children had initial control and then relapse. Three had interval flares. Two had no improvement. Injections were well tolerated, without significant adverse effects. Treatment was associated with an increase in total immunoglobulin E. Poor adherence complicated therapy in five patients. All 10 discontinued IFN\u2010\u03b3 for poor perceived efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with confirmed eczema herpeticum have evidence of impaired innate and adaptive immunity. IFN\u2010\u03b3 did not result in dramatic improvement in either subset. Specific evaluation for IFN\u2010\u03b3 production, function, or receptor defects may help predict response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13301","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T12:45:23Z","timestamp":1510836323000},"page":"686-689","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of children with recurrent eczema herpeticum and response to treatment with interferon\u2010gamma"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-837X","authenticated-orcid":false,"given":"Kavita","family":"Darji","sequence":"first","affiliation":[{"name":"Saint Louis University Hospital St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Frisch","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Adjei Boakye","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research Saint Louis University St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Siegfried","sequence":"additional","affiliation":[{"name":"Saint Louis University Hospital St. Louis MO USA"},{"name":"Cardinal Glennon Children's Medical Center St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12270"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.020"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12382"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203030-00004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24236"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2012.05384.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.04.065"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000034"},{"key":"e_1_2_5_11_1","first-page":"AB142","volume":"70","author":"Tobin C","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00896-X"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1345"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.192"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01356.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70026-P"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.799"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:47:31Z","timestamp":1695548851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/pde.13301"],"URL":"https:\/\/doi.org\/10.1111\/pde.13301","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}