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Aside from cosmetic concerns, these xanthomas are typically asymptomatic, but when generalized pruritus is a prominent associated symptom, clinicians should consider a different set of diagnoses that includes cholestasis of the liver. In this article we present two illustrative cases of children with cholestatic disease, pruritus, and xanthomas and discuss other disorders that may include this triad.<\/jats:p>","DOI":"10.1111\/pde.13306","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T12:45:23Z","timestamp":1510836323000},"source":"Crossref","is-referenced-by-count":4,"title":["The triad of pruritus, xanthomas, and cholestasis: Two cases and a brief review of the literature"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-5556","authenticated-orcid":false,"given":"Hadley J.","family":"Pearson","sequence":"first","affiliation":[{"name":"University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy L.","family":"Mosser","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie K.","family":"Jacks","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"350","article-title":"New JAG1 mutation causing Alagille syndrome presenting with severe hypercholesterolemia: case report with emphasis on genetics and lipid abnormalities","volume":"102","author":"Hannoush ZC","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01458.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05576.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000731)93:3<250::AID-AJMG18>3.0.CO;2-A"},{"key":"e_1_2_5_6_1","unstructured":"ParisiM GlassI.Joubert syndrome and related disorders.GeneReviews2003. 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