{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:40:34Z","timestamp":1791855634964,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Advancing Translational Sciences awarded to the University of Kansas Medical Center for \u201cFrontiers: The Heartland Institute for Clinical and Translational Research\u201d","award":["KL2TR000119"],"award-info":[{"award-number":["KL2TR000119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>\n                      Stevens\u2010Johnson syndrome (\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      ) and toxic epidermal necrolysis (\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      ) are life\u2010threatening cutaneous reactions, typically to drugs or infection. The incidence and outcomes of these conditions in children are unknown. The objective of this study was to report the overall burden of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis in children in the United States.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort analysis of children and adolescents younger than 18\u00a0years of age using the 2009 and 2012 Kids' Inpatient Database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 1486 children and adolescents hospitalized with a diagnosis of Stevens\u2010Johnson syndrome or toxic epidermal necrolysis. The national incidence per 100\u00a0000 was 6.3 for Stevens\u2010Johnson syndrome, 0.7 for Stevens\u2010Johnson syndrome\/toxic epidermal necrolysis overlap syndrome, and 0.5 for toxic epidermal necrolysis. The highest incidence in children was in those aged 11\u201015\u00a0years (38.4 per 100\u00a0000). Toxic epidermal necrolysis and Stevens\u2010Johnson syndrome\/toxic epidermal necrolysis overlap syndrome were associated with longer stay, greater mortality, and higher hospital charges than those with Stevens\u2010Johnson syndrome. Hospital mortality was highest in children with toxic epidermal necrolysis and in children aged 0\u20105\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis in children is higher than reported in adults, and there are significant age\u2010based variations in incidence and outcomes across the pediatric population. Further study is needed to determine the most effective treatment strategies to reduce costs and improve outcomes in children hospitalized with severe cutaneous reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.13383","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T06:10:54Z","timestamp":1515564654000},"page":"182-187","source":"Crossref","is-referenced-by-count":59,"title":["Incidence, outcomes, and resource use in children with Stevens\u2010Johnson syndrome and toxic epidermal necrolysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-2658","authenticated-orcid":false,"given":"James W.","family":"Antoon","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Children's Hospital University of Illinois Hospital &amp; Health Sciences System Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Children's Mercy Hospitals and Clinics Kansas City MO USA"},{"name":"Division of Infectious Diseases Children's Mercy Hospitals and Clinics Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Children's Mercy Hospitals and Clinics Kansas City MO USA"},{"name":"Division of Infectious Diseases Children's Mercy Hospitals and Clinics Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Children's Hospital University of Illinois Hospital &amp; 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