{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:24:16Z","timestamp":1788938656922,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011866","name":"Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["NIH\/NCATS Colorado Grant Number UL1 TR001082"],"award-info":[{"award-number":["NIH\/NCATS Colorado Grant Number UL1 TR001082"]}],"id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>There are no reliably effective, well\u2010tolerated topical agents for the treatment of hyperhidrosis. We sought to evaluate the efficacy and tolerability of oxybutynin 3% gel in adolescents and young adults with primary focal hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with severe axillary hyperhidrosis were treated with topical oxybutynin 3% gel for 4 weeks. Response to treatment was assessed by calculating change in Hyperhidrosis Disease Severity Score from baseline to weeks 1 and 4. Change in health\u2010related quality of life was assessed using the Children's Dermatology Life Quality Index or the Dermatology Life Quality Index. Adverse effects were evaluated using patient diaries, investigator global review, and physical examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 10 patients aged 13\u201024 enrolled, seven completed the study. Of those who completed the study, four (57.1%) reported reduction in axillary Hyperhidrosis Disease Severity Score at week 1 and all seven (100%) at week 4. Six patients (85.7%) reported reduction in Children's Dermatology Life Quality Index or Dermatology Life Quality Index score. Anticholinergic adverse effects were infrequent. The majority of treatment\u2010related adverse events were mild to moderate in severity. One patient experienced a severe adverse event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oxybutynin 3% gel reduced hyperhidrosis severity and improved health\u2010related quality of life in this small pilot study. Safety and efficacy should be further evaluated in a large, prospective, placebo\u2010controlled study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13404","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T09:58:59Z","timestamp":1516010339000},"page":"208-212","source":"Crossref","is-referenced-by-count":26,"title":["Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-5504","authenticated-orcid":false,"given":"Nicholas V.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Dermatology Akron Children's Hospital Akron OH USA"},{"name":"Department of Internal Medicine Northeast Ohio Medical University Rootstown OH USA"},{"name":"Department of Pediatrics Northeast Ohio Medical University Rootstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Gralla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Colorado Aurora CO USA"},{"name":"Department of Biostatistics and Informatics School of Medicine University of Colorado Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Abbott","sequence":"additional","affiliation":[{"name":"College of Medicine Drexel University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Bruckner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Colorado Aurora CO USA"},{"name":"Department of Dermatology School of Medicine University of Colorado Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6130.84"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12142"},{"key":"e_1_2_6_5_1","first-page":"S26","article-title":"Transdermal systems for overactive bladder: principles and practice","volume":"5","author":"Staskin DR","year":"2003","journal-title":"Rev Urol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0022-3565(25)20848-5","article-title":"The anticholinergic activity of agents indicated for urinary incontinence is an important property for effective control of bladder dysfunction","volume":"251","author":"Noronha\u2010Blob L","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_7_1","first-page":"57","article-title":"Clinical utility of transdermal delivery of oxybutynin gel via a metered\u2010dose pump in the management of overactive bladder","volume":"4","author":"Wagg A","year":"2012","journal-title":"Res Rep Urol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.202"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb16953.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T21:17:53Z","timestamp":1751231873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/pde.13404"],"URL":"https:\/\/doi.org\/10.1111\/pde.13404","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,15]]}}}