{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:31:42Z","timestamp":1783049502288,"version":"3.54.6"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient with extensive multisystem overgrowth caused by a somatic gain of function <jats:styled-content style=\"fixed-case\">PIK<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010mutation is described. This case is an example of the clinical diversity of the <jats:styled-content style=\"fixed-case\">PIK<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010Related Overgrowth Spectrum (<jats:styled-content style=\"fixed-case\">PROS<\/jats:styled-content>) as the patient had overlapping features of Congenital Lipomatous Overgrowth Vascular malformations Epidermal nevi and Skeletal abnormalities (<jats:styled-content style=\"fixed-case\">CLOVES<\/jats:styled-content>) syndrome and Megalencephaly\u2010Capillary malformation Polymicrogyria (<jats:styled-content style=\"fixed-case\">MCAP<\/jats:styled-content>) syndrome and underlines the utility of this umbrella term.<\/jats:p>","DOI":"10.1111\/pde.13441","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T08:52:43Z","timestamp":1519894363000},"source":"Crossref","is-referenced-by-count":10,"title":["Phosphatidylinositol\u20104,5\u2010bisphosphate 3\u2010kinase catalytic subunit alpha (PIK3CA)\u2010related overgrowth spectrum: A brief report"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-572X","authenticated-orcid":false,"given":"Pieter","family":"Denorme","sequence":"first","affiliation":[{"name":"Department of Dermatology, Microbiology, and Immunology Universitaire Ziekenhuizen Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Anne","family":"Morren","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Microbiology, and Immunology Universitaire Ziekenhuizen Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Hollants","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Universitaire Ziekenhuizen Leuven Leuven 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