{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:12:53Z","timestamp":1789013573124,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We present a patient in whom a combination of perinuclear antineutrophil cytoplasmic antibody\u2013positive vasculitis, oligoarthritis, tendinitis, and myositis was considered to be associated with isotretinoin use. Discontinuation of the drug resulted in complete clinical and biochemical remission (normalization of perinuclear antineutrophil cytoplasmic antibody titer). Although we were unable to prove causality, no other underlying cause for the patient's course was found. We report this occurrence to bring it to the attention of physicians prescribing isotretinoin.<\/jats:p>","DOI":"10.1111\/pde.13445","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T01:43:31Z","timestamp":1523497411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Perinuclear antineutrophil cytoplasmic antibody\u2013positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15\u2010year\u2010old boy: Case report and review of literature"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9421-9932","authenticated-orcid":false,"given":"Thomas C.","family":"Mangodt","sequence":"first","affiliation":[{"name":"Department of Pediatrics Queen Paola Children's Hospital Antwerp Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Joos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Queen Paola Children's Hospital Antwerp Belgium"},{"name":"Department of Pediatric Rheumatology University Hospital of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Siozopoulou","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter\u2010Jan","family":"Cortoos","sequence":"additional","affiliation":[{"name":"Pharmacy University Hospital of Brussels Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Baeten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Queen Paola Children's Hospital Antwerp Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Docx","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Queen Paola Children's Hospital Antwerp Belgium"},{"name":"Department of Chronic Pediatric Diseases and Nephrology Queen Paola Children's Hospital Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiel","family":"van den Akker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Queen Paola Children's Hospital Antwerp Belgium"},{"name":"Department of Pediatric Hematology and Oncology University Hospital of Brussels Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"key":"e_1_2_4_2_1","volume-title":"Summary of Product Characteristics: Isotretinoin","author":"Federal Agency for Medicines and Health Products","year":"2017"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12464"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70053-2"},{"key":"e_1_2_4_5_1","first-page":"129","article-title":"Isotretinoin\u2010induced vasculitis imitating polyarteritis nodosa, with perinuclear antineutrophil cytoplasmic antibody in titers correlated with clinical symptoms","volume":"64","author":"Chochrad D","year":"1997","journal-title":"Revue du Rhumatisme (English ed)"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(95)80039-5"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00118-9"},{"key":"e_1_2_4_9_1","first-page":"94","article-title":"Muscular damage during isotretinoin treatment","volume":"125","author":"Heudes AM","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_4_10_1","first-page":"402","article-title":"Acute arthritis during isotretinoin treatment","volume":"121","author":"Callot V","year":"1994","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)80321-8"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1001\/archinte.1984.00350210200037","article-title":"Acute arthritis during isotretinoin treatment for acne","volume":"144","author":"Matsuoka LY","year":"1984","journal-title":"Arch Intern Med"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150013"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb02159.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8320-4"},{"key":"e_1_2_4_16_1","first-page":"12","article-title":"Drug\u2010induced vasculitis: a clinical and pathological review","volume":"70","author":"Radic M","year":"2012","journal-title":"Neth J Med"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.12.003"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2245-z"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.10.769"},{"key":"e_1_2_4_20_1","first-page":"587","article-title":"Minocycline\u2010induced arthritis","volume":"16","author":"Knights SE","year":"1998","journal-title":"Clin Exp Rheumatol"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:13:20Z","timestamp":1695496400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,11]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/pde.13445"],"URL":"https:\/\/doi.org\/10.1111\/pde.13445","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733422591.793553295","asserted-by":"object"}]},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,11]]},"assertion":[{"value":"2018-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}