{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:09:54Z","timestamp":1777961394694,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sclerodermatous graft\u2010versus\u2010host disease is a subtype of cutaneous chronic graft\u2010versus\u2010host disease that is characterized by sclerosis of the skin and subcutaneous tissue, resulting in debilitating contractures, among other life\u2010threatening complications. Children with sclerodermatous graft\u2010versus\u2010host disease are at high risk of developing nonmelanoma skin cancer because of several risk factors, including young age at transplantation, prolonged immunosuppression, and exposure to photosensitizing antimicrobial prophylaxis such as voriconazole. The immunosuppression required to treat sclerodermatous graft\u2010versus\u2010host disease makes effectively treating nonmelanoma skin cancer and sclerodermatous graft\u2010versus\u2010host disease in the same patient challenging. We describe a challenging case of a 6\u2010year\u2010old boy with a history of sclerodermatous graft\u2010versus\u2010host disease and voriconazole exposure presenting with squamous cell carcinoma in\u00a0situ on the left temple and actinic keratoses on the scalp treated with topical chemotherapy agents.<\/jats:p>","DOI":"10.1111\/pde.13473","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T19:39:37Z","timestamp":1521833977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A pediatric case of squamous cell cancer in\u00a0situ in the setting of sclerodermatous graft\u2010versus\u2010host disease and voriconazole treatment"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-838X","authenticated-orcid":false,"given":"Alvin W.","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine Yale University New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah E.","family":"Lalor","sequence":"additional","affiliation":[{"name":"University of California, San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Bellodi Schmidt","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minnelly","family":"Luu","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"209","article-title":"Extracorporeal photo\u2010apheresis for the treatment of steroid resistant graft versus host disease","volume":"41","author":"Baird K","year":"2010","journal-title":"Cancer Res"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3411"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.023"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7052"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.57"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01301.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.1550"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.07.005"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204750"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108188"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.07.025"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31828e5d96"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.033"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2012.01.001"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506197"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:13:12Z","timestamp":1695510792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/pde.13473"],"URL":"https:\/\/doi.org\/10.1111\/pde.13473","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}