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We report a case of an Asian male infant who was found to have hyper\u2010immunoglobulin D syndrome in the absence of fever. His skin manifestations included cephalic pustulosis as well recurrent transient and fixed pink plaques and nodules on the face and extremities. Subsequent examination revealed hyper\u2010immunoglobulin D syndrome with two novel allelic mutations in the mevalonate kinase gene: c.895G &gt; A (p.D299N) and c.1168C &gt; T (p.Q390). It is important for dermatologists to recognize the varied cutaneous presentations of hyper\u2010immunoglobulin D syndrome because rapid diagnosis and treatment can significantly affect outcomes.<\/jats:p>","DOI":"10.1111\/pde.13488","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T07:16:58Z","timestamp":1522394218000},"page":"482-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyper\u2010immunoglobulin D syndrome with novel mutations in an afebrile infant"],"prefix":"10.1111","volume":"35","author":[{"given":"Simi D.","family":"Cadmus","sequence":"first","affiliation":[{"name":"School of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-2892","authenticated-orcid":false,"given":"Reid","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Medicine Dell Medical School University of Texas Austin TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dell Medical School University of Texas Austin TX USA"},{"name":"Dell Children's Medical Center Austin TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moise L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Medicine Dell Medical School University of Texas Austin TX USA"},{"name":"Department of Pediatrics Dell Medical School University of Texas Austin TX USA"},{"name":"Dell Children's Medical Center Austin TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Z.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Dell Medical School University of Texas Austin TX USA"},{"name":"Department of Pediatrics Dell Medical School University of Texas Austin TX USA"},{"name":"Dell Children's Medical Center Austin TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-015-1985-y"},{"key":"e_1_2_4_3_1","first-page":"136","volume-title":"Andrews\u2019 Diseases of the Skin","author":"James WD","year":"2016"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00342.x"},{"key":"e_1_2_4_5_1","unstructured":"Infevers\u2014MVK sequence variants. 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