{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:56Z","timestamp":1772160896017,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous leishmaniasis has an incidence of 0.7\u20131.2\u00a0million cases per year and represents a growing concern in the outpatient dermatologic practice in Europe because of imported cases due to increased travel to risk areas and to immigration phenomena. When dealing with children, the treatment can be challenging because of side effects and pain of classic antimonial therapy leading to poor rates of course completion and requirement of sedation for several children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied three cases of cutaneous leishmaniasis in pediatric patients, between the ages of 3 and 6\u00a0years of age, treated with oral fluconazole. We examined the efficacy, the tolerability, the safety profile and the cosmetic result of fluconazole at a dose of 6\u00a0mg\/kg\/daily for 6\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients had a complete resolution of their lesions with minimal scarring. No adverse effect was reported. The leishmaniasis species identified were\n                      <jats:italic>L.\u00a0major<\/jats:italic>\n                      or\n                      <jats:italic>L.\u00a0tropica<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Considering sides effects and the parents\u2019 and the clinician's concern for systemic treatment in the pediatric population, fluconazole represents a valid, safe and easily manageable option for Old World cutaneous leishmaniasis in pediatric outpatients caused by\n                      <jats:italic>L.\u00a0major<\/jats:italic>\n                      or\n                      <jats:italic>L.\u00a0tropica<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-4575","authenticated-orcid":false,"given":"Stefania","family":"Barruscotti","sequence":"additional","affiliation":[{"name":"Department of Clinical\u2010Surgical, Diagnostic and Pediatric Science Institute of Dermatology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Bossi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5898-6448","authenticated-orcid":false,"given":"Valeria","family":"Brazzelli","sequence":"additional","affiliation":[{"name":"Department of Clinical\u2010Surgical, Diagnostic and Pediatric Science Institute of Dermatology Fondazione IRCCS Policlinico San Matteo 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