{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:19:00Z","timestamp":1786925940982,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Omeprazole significantly increases duodenal prostaglandin E<jats:sub>2<\/jats:sub> synthesis. Prostaglandins are involved in hair growth regulation: prostaglandin E<jats:sub>2<\/jats:sub> and prostaglandin F<jats:sub>2<\/jats:sub> alpha stimulate hair growth, and prostaglandin D<jats:sub>2<\/jats:sub> has an inhibitory effect. The use of omeprazole can cause acquired generalized hypertrichosis by increasing prostaglandin E<jats:sub>2<\/jats:sub> levels.<\/jats:p>","DOI":"10.1111\/pde.13496","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T03:30:32Z","timestamp":1522121432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Omeprazole\u2010induced hypertrichosis in two children"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-9316","authenticated-orcid":false,"given":"Marta","family":"Elosua\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Nino Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-2265","authenticated-orcid":false,"given":"Minia","family":"Campos\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bancalari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Nino Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucero","family":"Noguera\u2010Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Nino Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hern\u00e1ndez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Nino Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Huerta\u2010Aragon\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Nino Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0335"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.03.012"},{"key":"e_1_2_4_4_1","first-page":"7296572","article-title":"Acquired localized hypertrichosis induced by rivastigmine","volume":"2016","author":"Imbern\u00f3n\u2010Moya A","year":"2016","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_4_5_1","first-page":"1576","article-title":"Diffuse alopecia associated with omeprazole","volume":"92","author":"Borum ML","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01484.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000200922"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199512020-00005"},{"key":"e_1_2_4_9_1","first-page":"469","article-title":"Evaluation of unexpected and toxic effects of omeprazole (Mopral) reported to the regional centers of pharmacovigilance during the first 22 postmarketing months","volume":"48","author":"Castot A","year":"1993","journal-title":"Therapie"},{"key":"e_1_2_4_10_1","first-page":"3165","article-title":"Cure of alopecia areata after eradication of Helicobacter pylori: a new association?","volume":"17","author":"Campuzano\u2010Maya G","year":"2011","journal-title":"World J Gastroenterol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182333820"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.06.055"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.026"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003122"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1341610"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00270.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:29:11Z","timestamp":1694996951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/pde.13496"],"URL":"https:\/\/doi.org\/10.1111\/pde.13496","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"2018-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}