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Cannabidiol, an active cannabinoid found in cannabis, is postulated to have antiinflammatory and analgesic effects. We report 3 cases of self\u2010initiated topical cannabidiol use in patients with epidermolysis bullosa in an observational study. One patient was weaned completely off oral opioid analgesics. All 3 reported faster wound healing, less blistering, and amelioration of pain with cannabidiol use. Although these results demonstrate promise, further randomized, double\u2010blind clinical trials are necessary to provide scientific evidence of our observed benefits of cannabidiol for the treatment of epidermolysis bullosa.<\/jats:p>","DOI":"10.1111\/pde.13545","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T11:19:42Z","timestamp":1526987982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Self\u2010initiated use of topical cannabidiol oil for epidermolysis bullosa"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-3373","authenticated-orcid":false,"given":"Malcolm P.","family":"Chelliah","sequence":"first","affiliation":[{"name":"School of Medicine Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Zinn","sequence":"additional","affiliation":[{"name":"Department of Dermatology West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoung","family":"Khuu","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce M. 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