{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:39:30Z","timestamp":1752669570819,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous manifestations can be found in many patients with hematologic disorders, including thalassemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with beta\u2010thalassemia major attending the pediatric department of Fayoum University Hospital from April 2016 to October 2016 (n\u00a0=\u00a0100) were compared with controls (n\u00a0=\u00a0100). Both groups underwent detailed history evaluation, clinical examination, and laboratory investigations, including complete blood count, liver and kidney function, serum ferritin, and thyroid profile. A single dermatologist conducted a clinical dermatologic examination for all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with thalassemia had a greater prevalence of xerosis (72%), pruritus (52%), idiopathic guttate hypomelanosis (22%), urticaria (16%), ephelides (freckles; 13%), and scars (13%) than controls (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001). We detected a significant relationship between serum ferritin and pruritus, xerosis, ephelides, idiopathic guttate hypomelanosis, urticaria, and age of patients with thalassemia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Children without thyroid abnormalities were more likely to have xerosis, pruritus, idiopathic guttate hypomelanosis, urticaria, and ephelides (86%) than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Although there was no significant difference in skin findings between patients who did and did not receive chelating agents (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05), a significant association was found between xerosis and the use of deferoxamine and deferiprone, whereas ephelides and urticaria were more common in patients receiving deferasirox.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because cutaneous manifestations are common in Egyptian patients with beta thalassemia major, regular dermatologic follow\u2010up is recommended for early management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13570","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T10:02:16Z","timestamp":1530007336000},"page":"639-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous manifestations in Egyptian children with beta\u2010thalassemia major: Relationship with serum ferritin, thyroid profile, and treatment modalities"],"prefix":"10.1111","volume":"35","author":[{"given":"Hanaa","family":"El\u2010Dash","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-2941","authenticated-orcid":false,"given":"Shereen","family":"Adel","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, and STDs Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2004.1.14"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091493"},{"key":"e_1_2_6_4_1","first-page":"1319","volume-title":"Wintrobe's Clinical Hematology","author":"Borgnapignatti C","year":"2004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.131081"},{"key":"e_1_2_6_6_1","first-page":"1867","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Piette WW","year":"1999"},{"key":"e_1_2_6_7_1","first-page":"24","article-title":"Which came first: the itch or the rash? Patient's scratching may be unrelated to a primary skin disease","volume":"51","author":"Levine N","year":"1996","journal-title":"Geriatrics"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04176.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmx035"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb01685.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2006.19.12.1397"},{"key":"e_1_2_6_12_1","first-page":"329","article-title":"Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta\u2010thalassemia major","volume":"9","author":"Moayeri H","year":"2006","journal-title":"Arch Iran Med"},{"key":"e_1_2_6_13_1","first-page":"1172","article-title":"Beta\u2010thalassemia","volume":"11","author":"Gallanello R","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"e_1_2_6_14_1","first-page":"2033","volume-title":"Nelson Textbook of Pediatrics","author":"Michael R","year":"2007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050241"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182374142"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:10:48Z","timestamp":1695017448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,26]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/pde.13570"],"URL":"https:\/\/doi.org\/10.1111\/pde.13570","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2018,6,26]]},"assertion":[{"value":"2018-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}