{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:13:03Z","timestamp":1770279183143,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a newborn boy with multinodular <jats:italic><jats:styled-content style=\"fixed-case\">NRAS<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutation\u2010negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5\u00a0months of age. This case may represent an infantile melanoma developing from a giant congenital melanocytic nevus or a congenital melanoma.<\/jats:p>","DOI":"10.1111\/pde.13595","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T09:48:13Z","timestamp":1531388893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, <i><scp>NRAS<\/scp><\/i> and <i><scp>BRAF<\/scp><\/i> mutation\u2010negative nodules"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-8865","authenticated-orcid":false,"given":"Daniel","family":"de la Rosa Carrillo","sequence":"first","affiliation":[{"name":"Department of Dermatology Oslo University Hospital Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Vindenes","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica A.","family":"Kinsler","sequence":"additional","affiliation":[{"name":"Paediatric Dermatology Department Great Ormond Street Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arild","family":"R\u00f8nnestad","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Ringstad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Radiology and Nuclear Medicine Oslo University Hospital Oslo 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