{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:35:18Z","timestamp":1788536118594,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infantile hemangiomas with minimal or arrested growth are vascular tumors with a proliferative component involving &lt;\u00a025% of their total surface area. They are commonly described as localized lesions and are mainly located on the lower body. Little has been described about segmental forms on the face and their associations with <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out a multicenter, retrospective, case\u2010series study involving 5 hospitals in Spain. Information was collected on cases of <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome featuring infantile hemangiomas with minimal or arrested growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frontotemporal and maxillary areas were the most frequently involved sites in our series. The upper eyelid and upper lip were the 2 locations most frequently associated with proliferation and ulceration. Four patients experienced spontaneous resolution, and the rest had a very good cosmetic outcome with oral treatment. Cerebral and cervical arterial anomalies were the most frequent extracutaneous findings associated with <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content>, followed by cerebral and ocular anomalies. Some unique associated disorders were fructose intolerance and retinoblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We present the largest case series of segmental facial infantile hemangiomas with minimal or arrested growth in <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome and emphasize the importance of recognizing these lesions in early infancy, because they can indicate <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome. The data presented suggest that infantile hemangiomas with minimal or arrested growth\u2013associated <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome does not seem to differ significantly from <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome with classic infantile hemangiomas, and thus the same recommendations for diagnosis, management, and therapy should be followed. Future studies with more patients could contribute to enlighten this specific subset.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13597","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T10:35:20Z","timestamp":1531132520000},"page":"622-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Infantile hemangioma with minimal or arrested growth as the skin manifestation of <scp>PHACE<\/scp> syndrome"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-1735","authenticated-orcid":false,"given":"Marta","family":"Valdivielso\u2010Ramos","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Infanta Leonor Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Ni\u00f1o Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Martin\u2010Santiago","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Son Espases Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-2265","authenticated-orcid":false,"given":"Minia","family":"Campos","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Conde","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Infanta Leonor Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"de la Cueva","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Infanta Leonor Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Lopez\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department Hospital La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00626.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1623"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.7.5.307"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.197"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.028"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-5-27"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14457"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00944.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.07.054"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12902"},{"key":"e_1_2_5_14_1","first-page":"487562","article-title":"Lymphatic malformation, retinoblastoma, or facial cleft: atypical presentations of PHACE syndrome","volume":"2015","author":"Fernandez\u2010Ibieta M","year":"2015","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2011.03.030"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1684\/ejd.2010.0959","article-title":"Abortive hemangiomas. 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