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The sum diameter of lesions showed a 61% decrease after 16.5 months of treatment, although after 18.5 months of treatment, a persistent lesion showed progression and metatypical characteristics; adverse events included persistent alopecia muscle cramps, dysgeusia, and amenorrhea. Despite these limitations, vismodegib may have a role in the treatment of some patients with xeroderma pigmentosum.<\/jats:p>","DOI":"10.1111\/pde.13610","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T05:29:25Z","timestamp":1536038965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Use of vismodegib for the treatment of multiple basal cell carcinomas in a patient with xeroderma pigmentosum"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-5647","authenticated-orcid":false,"given":"Efthymia","family":"Soura","sequence":"first","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Plaka","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clio","family":"Dessinioti","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Chasapi","sequence":"additional","affiliation":[{"name":"State Clinic of Dermatology \u2013 Venereology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-5272","authenticated-orcid":false,"given":"Christina","family":"Stefanaki","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Antoniou","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stratigos","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0616-2"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70198-1"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13080"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.012"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12526"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0186"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.04.045"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13754"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30072-4"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:44:13Z","timestamp":1694861053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,3]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/pde.13610"],"URL":"https:\/\/doi.org\/10.1111\/pde.13610","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,3]]},"assertion":[{"value":"2018-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}