{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:17:18Z","timestamp":1755926238989,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Plantar hyperhidrosis can have severe social effects on children and adolescents. Therapeutic options include antiperspirants and surgical interventions (eg, sympathectomy). Botulinum type A toxin is approved for axillary hyperhidrosis in adults only. The aim of the study was the determination of effect and safety of botulinum type A toxin in plantar hyperhidrosis in juvenile patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children and adolescents with idiopathic focal plantar hyperhidrosis were treated with 50\u2010100\u00a0U of botulinum type A toxin per sole. Local anesthesia was provided using topical eutectic mixture of local anesthetics cream and ice, in combination with midazolam as an anxiolytic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients (aged 12\u201017) were included in the study. Best results were achieved with a dose of 75\u2010100\u00a0U of botulinum type A toxin per sole. Two patients did not benefit from the therapy, and 11 (73%) were satisfied with the results. Nine patients (60%) experienced pain at the injection site for a maximum duration of 3\u00a0days. One patient reported transient focal weakness for 4\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Botulinum type A toxin seems to be a safe secondary treatment option for plantar hyperhidrosis in adolescents aged 12 and older. A dose of 75\u2010100\u00a0U per sole resulted in a good therapeutic effect of variable duration in most patients. There were no severe side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13628","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T08:20:07Z","timestamp":1536049207000},"page":"784-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sweaty feet in adolescents\u2014Early use of botulinum type A toxin in juvenile plantar hyperhidrosis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-865X","authenticated-orcid":false,"given":"Matthias K.","family":"Bernhard","sequence":"first","affiliation":[{"name":"Department of Neuropediatrics University Hospital of Children Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Syrbe","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2755"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12142"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X11434506"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.01.012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007817"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01751.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/308650"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2008.04.014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.875559"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.7547\/0980156"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.012"},{"key":"e_1_2_5_14_1","first-page":"147","article-title":"Type A botulinum toxin: a new treatment for axillary and palmar hyperhidrosis","volume":"1","author":"Rusciani L","year":"2002","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_15_1","first-page":"167","article-title":"Botulinum toxin\u2010A therapy for palmar and plantar hyperhidrosis","volume":"102","author":"Sevim S","year":"2002","journal-title":"Acta Neurol Bel"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32337.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2009.08072"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S60389"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:43:16Z","timestamp":1694860996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/pde.13628"],"URL":"https:\/\/doi.org\/10.1111\/pde.13628","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2018,9,4]]},"assertion":[{"value":"2018-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}