{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:40:49Z","timestamp":1778290849237,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The extrathyroid manifestations of Graves disease (GD) include thyroid orbitopathy, dermopathy, and acropachy. Thyroid dermopathy (TD), also known as pretibial myxedema, classically presents as nonpitting edema or plaquelike lesions on the pretibial region, while thyroid acropachy (TA) is seen in cases of severe TD, characterized by soft tissue swelling and clubbing of fingers and toes, as well as a periosteal reaction of the bones of the hands and feet. Both TD and TA are rare manifestations of thyroid disease and uncommonly reported in pediatric patients. Our aim was to increase awareness of dermatological manifestations associated with pediatric GD and review the literature of pediatric thyroid dermopathy as well as report a case of acropachy in a child.<\/jats:p>","DOI":"10.1111\/pde.13670","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T11:02:33Z","timestamp":1536231753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Thyroid dermopathy and acropachy in pediatric patients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-4125","authenticated-orcid":false,"given":"Christina N.","family":"Kraus","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Sodha","sequence":"additional","affiliation":[{"name":"Department of Dermatology Duke University Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Vaidyanathan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Children's National Health System Washington District of Columbia"},{"name":"George Washington University School of Medicine &amp; Health Sciences Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Yasmine","family":"Kirkorian","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine &amp; Health Sciences Washington District of Columbia"},{"name":"Division of Dermatology Children's National Health System Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.2.438"},{"key":"e_1_2_5_3_1","first-page":"386081","article-title":"Cutaneous manifestations of thyroid disease: a case of thyroid\u2010induced myxedema","volume":"2011","author":"Shroff A","year":"2011","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02394.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1973.04160050087018"},{"issue":"2","key":"e_1_2_5_6_1","first-page":"95","article-title":"Elephantiasic pretibial myxoedema: study of five cases","volume":"52","author":"Niang SO","year":"2007","journal-title":"Dakar Med"},{"issue":"6","key":"e_1_2_5_7_1","first-page":"440","article-title":"Graves\u2019 disease in childhood","volume":"29","author":"Maldonado Regalado S","year":"1988","journal-title":"An Esp Pediatr"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320028"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00521"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.323"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506050-00003"},{"issue":"2","key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archderm.1980.01640260081021","article-title":"Thyroid acropachy","volume":"116","author":"Goette DK","year":"1980","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020746"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2009.01.006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00278-6"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03850.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503322021124"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250050137761"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/19381980.2014.981078"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70132-L"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446699"},{"issue":"6","key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/jid.1949.53","article-title":"Local injections of a preparation of hyaltjronidase in the treatment of localized (pretibial) myxedema","volume":"12","author":"Grais ML","year":"1949","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.10.001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0097-2"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2010.00693.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12141"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:44:31Z","timestamp":1694861071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/pde.13670"],"URL":"https:\/\/doi.org\/10.1111\/pde.13670","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]},"assertion":[{"value":"2018-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}