{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:02:34Z","timestamp":1789084954931,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a chronic condition that is predominantly found in pediatric patients and commonly presents therapeutic challenges. The management of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>encompasses a variety of factors, and the pillars of optimal management revolve around skin barrier repair and antiinflammatory, antimicrobial, and antipruritic treatment.<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>management guidelines exist in various geographic regions globally. The purpose of this review was to compare international guidelines to highlight the similarities and variances among populations and skin types. Comparisons were made for recommendations regarding moisturization, bathing, wet wrap therapy, topical corticosteroids, topical calcineurin inhibitors, antihistamines, antipruritics, antibiotics, systemic immunosuppressants, and biologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search of the PubMed,<jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>databases was performed for published guidelines in each geographic region. Inclusion criteria included publications available in English that were established by a dermatological association or group including dermatologists, pertained to the treatment of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>in humans, were the most recent guidelines available that were published between 2007 and 2018, and included comprehensive treatment recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Publications from Europe, North America, Asia, the Asia\u2010Pacific region, Australia, and Africa were reviewed, encompassing 14 guidelines. Notable diversity exists across these guidelines regarding recommendations for moisturization and bathing, as well as topical and systemic therapies for<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Due to the heterogeneity of the disease and regional treatment accessibility, complete standardization of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>management guidelines may be difficult. Nevertheless, more consensus on management guidelines is needed, and recommendations should be updated as new treatment modalities become available.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13678","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T16:41:13Z","timestamp":1539189673000},"page":"36-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A comparison of international management guidelines for atopic dermatitis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-8223","authenticated-orcid":false,"given":"Lindsey M.","family":"LePoidevin","sequence":"first","affiliation":[{"name":"University of Arizona College of Medicine Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7510-9428","authenticated-orcid":false,"given":"Vivian Y.","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medicine Dermatology Division University of Arizona Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.125"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2015.53319"},{"issue":"10","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.47102\/annals-acadmedsg.V45N10p439","article-title":"Guidelines for the management of atopic dermatitis in Singapore","volume":"45","author":"Tay YK","year":"2016","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-016-0229-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.5.563"},{"key":"e_1_2_7_10_1","first-page":"365","article-title":"It's a wrap: the use of wet pajamas in wet\u2010wrap dressings for atopic dermatitis","volume":"17","author":"Barham KL","year":"2005","journal-title":"Dermatol Nurs"},{"key":"e_1_2_7_11_1","unstructured":"National Collaborating Centre for Women's and Children's Health (UK).National Institute for Health and Clinical Excellence: Guidance. 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