{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:42Z","timestamp":1787015982860,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent reports indicate that tufted angioma is a rare vascular neoplasm that manifests more frequently at birth than previously thought. Few studies specifically address congenital presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      We analyzed the clinicopathological characteristics, clinical course, and treatment of congenital tufted angioma (\n                      <jats:styled-content style=\"fixed-case\">cTA<\/jats:styled-content>\n                      ) and evaluated variables that were indicative of problematic lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed an observational retrospective study of 30 patients with\n                      <jats:styled-content style=\"fixed-case\">cTA<\/jats:styled-content>\n                      in 9 Spanish hospitals over a 14\u2010year period. Histopathology and immunohistochemistry studies were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Congenital tufted angioma mainly affected the limbs (56.67%), followed by the face and\/or neck (23.33%). Almost three\u2010quarters of facial\n                      <jats:styled-content style=\"fixed-case\">cTA<\/jats:styled-content>\n                      were located over the mandibular area. Immunohistochemically, proliferating cells expressed markers of endothelial cells, with some clusters of cells, especially at the periphery of the aggregates, showing positivity for podoplanin. As no associated complications were observed in 66.67% of cases, no treatment was started.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Data were collected retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings emphasize the clinical features and course of\n                      <jats:styled-content style=\"fixed-case\">cTA<\/jats:styled-content>\n                      . The possibility of\n                      <jats:styled-content style=\"fixed-case\">cTA<\/jats:styled-content>\n                      should be considered when a poorly defined congenital infiltrative vascular tumor with(out) overlying hirsutism appears over the mandibular area. Location on the face and\/or neck requires a more comprehensive workup, since potentially severe complications often appear early.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.13683","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T03:45:56Z","timestamp":1539575156000},"page":"808-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Congenital tufted angioma: A multicenter retrospective study of 30 cases"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-8904","authenticated-orcid":false,"given":"Marta","family":"Feito\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario La Paz Madrid 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