{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:45:36Z","timestamp":1772120736079,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melanoma is a rare diagnosis in the pediatric population. Differences in incidence, presentation, and survival distinguish pediatric melanoma from adult melanoma. In order to improve our understanding of pediatric melanoma, our case series investigates differences in incidence, age of onset, and anatomic site between male and female pediatric melanoma patients in Colorado between 1988 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All data were gathered from the Colorado Central Cancer Registry. A request for de\u2010identified data on pediatric melanoma patients between 1988 and 2015 was made by the University of Colorado Department of Dermatology. Chi\u2010square tests were used to compare the differences reported in melanoma between sex, age\u2010groups, and site of lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 256 cases of melanoma were reported in Colorado in patients &lt;\u00a020\u00a0years of age between 1988 and 2015. Overall incidence of pediatric melanoma in Colorado increased from 1988 to 1999 but declined from 2001 to 2011. There was a significant predominance of female cases in the 10\u201014 age\u2010group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0477) and 15\u201019 age\u2010group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0472). Both groups had increased incidence of melanoma with increasing age. The mean age of onset for both sexes was 16\u00a0years old. Boys were more likely to have melanoma of the scalp and neck (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0523) and less likely to have melanoma of the leg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among the pediatric population, girls 10\u201014 and 15\u201019\u00a0years old are at a significantly increased risk of melanoma compared to boys in these age\u2010groups. Our study found sex\u2010specific differences in anatomic site consistent with prior literature. Further investigations should aim to identify causes for these sex\u2010specific differences in order to better guide public health initiatives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13747","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T12:45:47Z","timestamp":1550839547000},"page":"219-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pediatric melanoma: Characterizing 256 cases from the Colorado Central Cancer Registry"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-7623","authenticated-orcid":false,"given":"Nazanin","family":"Kalani","sequence":"first","affiliation":[{"name":"University of Colorado School of Medicine Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Guidry","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Hospital Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Farahi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Hospital Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie B.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Colorado School of Medicine Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Dellavalle","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Hospital Aurora Colorado"},{"name":"Department of Dermatology Denver Denver Veterans Affairs Medical Center (VAMC) Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory A.","family":"Dunnick","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Hospital Aurora Colorado"},{"name":"Department of Dermatology Denver Denver Veterans Affairs Medical Center (VAMC) Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Melanoma of the Skin.SEER Stat Fact Sheets National Cancer Institute\u2014Surveillance Epidemiology and End Results Program;2016. Available at:https:\/\/seer.cancer.gov\/statfacts\/html\/melan.html. Accessed January 9 2018."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.02.050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.06.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2520"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.01078.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2964"},{"key":"e_1_2_8_8_1","unstructured":"U.S. Cancer Statistics Working Group.United States Cancer Statistics: 1999\u20102014 Incidence and Mortality Web\u2010based Report. Atlanta: U.S. Department of Health and Human Services Centers for Disease Control and Prevention and National Cancer Institute;2017. 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