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We here report regarding five new patients with <jats:styled-content style=\"fixed-case\">HCH<\/jats:styled-content> who exhibited <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> lesions began in childhood, and they were extensive. These lesions were located on the torso, the abdomen, and the face, in addition to the typical skin fold sites. Other skin lesions were frequently reported: caf\u00e9\u2010au\u2010lait macules, melanocytic nevi, lentigines, and seborrheic keratosis. The Lys650Thr mutation was the predominant reported mutation of <jats:italic><jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>3<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pde.13748","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T11:18:21Z","timestamp":1550143101000},"page":"242-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acanthosis nigricans, hypochondroplasia, and <i><scp>FGFR<\/scp>3<\/i> mutations: Findings with five new patients, and a review of the literature"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0308-9488","authenticated-orcid":false,"given":"Louise","family":"Muguet Guenot","sequence":"first","affiliation":[{"name":"Department of Dermatology CHU Nantes Nantes 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