{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:13:45Z","timestamp":1791213225921,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Palmar hyperlinearity is a typical clinical feature of <jats:italic>Filaggrin gene<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic>) null mutations. There are reports of <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations and allergic sensitization; however, reports on the relationship between palmar hyperlinearity to sensitization are limited. This study aimed to examine the association between palmar hyperlinearity and sensitization in atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional, case\u2010control study included children \u02c2 6\u00a0years old with moderate\u2010severe <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> whose parents consented for mutation analysis and photographic documentation. Each child underwent genotyping to detect the eight most prevalent <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations in the Japanese population: R501X, 3321delA, S1695X, Q1701X, S2554X, S2889X, S3296X, and K4022X. Clinical features and parameters including egg\u2010specific IgE were examined, and palm photographs were evaluated by 12 trained dermatologists blinded to genotyping results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 57 patients (age range, 2\u00a0months to 5\u00a0years; median, 22\u00a0months), 16 were heterozygotes and three were compound heterozygotes. Palmar hyperlinearity, as recognized by more than two\u2010thirds of dermatologists, was significantly associated with <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.98, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a02.1\u201023.7), and this association was observed especially in children over 2\u00a0years. Cross\u2010shaped crease of the thenar eminence, as known in previous reports, also demonstrated significant correlation with <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutation. When the children were divided according to the presence or absence of palmar hyperlinearity, the egg white\u2013specific IgE was significantly higher in the hyperlinearity group (55.9 vs 18.3\u00a0IU\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Palmar hyperlinearity indicates possible inherited barrier abnormalities of the skin in early childhood. Its identification may help to predict a more accurate prognosis, such as sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13752","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T10:35:54Z","timestamp":1551263754000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Palmar hyperlinearity in early childhood atopic dermatitis is associated with filaggrin mutation and sensitization to egg"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-2137","authenticated-orcid":false,"given":"Tatsuki","family":"Fukuie","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hamamatsu University School of Medicine Hamamatsu Japan"},{"name":"Division of Allergy Department of Medical Subspecialties National Center for Child Health and Development Tokyo 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