{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:48:59Z","timestamp":1784767739606,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009570","name":"Srinakharinwirot University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of topical 0.1% adapalene gel compared to 0.025% tretinoin cream in the treatment of childhood <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An 8\u2010week, randomized, split\u2010neck, comparative study between topical 0.1% adapalene gel and 0.025% tretinoin cream for the treatment of neck hyperpigmentation associated with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> was performed. M index measured by a narrowband reflectance spectrophotometer and both investigator's global evaluation (<jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>) and parent's global evaluation (<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>) scales were used to evaluate efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference between 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\u2010associated hyperpigmentation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.56). Mean differences in M indices between week 0 and week 8 of 0.1% adapalene and 0.025% tretinoin treatment were 24.2\u00a0\u00b1\u00a07.9% and 23.8\u00a0\u00b1\u00a08.3% improvement, respectively. Regarding treatment efficacy, 90.0% and 85.0% of participants had more than 75% improvement in <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. In addition, 75.0% and 65.0% of participants had more than 75.0% improvement in <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content> in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Lack of histopathological evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found no significant difference between topical 0.1% adapalene gel and 0.025% tretinoin in the treatment of <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13799","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T23:45:15Z","timestamp":1552952715000},"page":"330-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-988X","authenticated-orcid":false,"given":"Arucha","family":"Treesirichod","sequence":"first","affiliation":[{"name":"Division of Pediatric Dermatology Department of Pediatrics Faculty of Medicine Srinakharinwirot University  Ongkharak Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthida","family":"Chaithirayanon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology Department of Pediatrics Faculty of Medicine Srinakharinwirot University  Ongkharak Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattakarn","family":"Wongjitrat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Faculty of Medicine Srinakharinwirot University  Ongkharak Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.1515"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.108.1.133b"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680070039003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.147838"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200910040-00005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0185-2"},{"key":"e_1_2_6_8_1","first-page":"621","article-title":"A review of the use of adapalene for the treatment of acne vulgaris","volume":"3","author":"Piskin S","year":"2007","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_6_9_1","first-page":"159","article-title":"Topical tretinoin in acanthosis nigricans","volume":"62","author":"Lahiri K","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5070\/D37MF6G290","article-title":"Acanthosis nigricans: a practical approach to evaluation and management","volume":"14","author":"Higgins SP","year":"2008","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018096"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-1-173"},{"key":"e_1_2_6_13_1","first-page":"290","article-title":"Comparison of long\u2010pulsed alexandrite laser and topical tretinoin\u2010ammonium lactate in axillary acanthosis nigricans: a case series of patients in a before\u2010after trial","volume":"7","author":"Ehsani A","year":"2016","journal-title":"Caspian J Intern Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415591117"}],"container-title":["Pediatric 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