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We describe two cases of piebaldism, in whom the remarkable asymmetric distribution of the depigmented patches in a connected, contiguous pattern across the legs provides embryologic insights. This finding is not explained by the traditional theory that melanocytic migration only originates in the neural crest and progresses unilaterally down each leg. We propose that our cases, and other similar cases, can be explained by a recent theory of mesodermal melanocyte migration.<\/jats:p>","DOI":"10.1111\/pde.13831","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T02:50:00Z","timestamp":1555296600000},"page":"511-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Striking contiguous depigmentation across the lower limbs in piebaldism and its implications for understanding melanocytic migration and development"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-747X","authenticated-orcid":false,"given":"Colton H.","family":"Funkhouser","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine  Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica A.","family":"Kinsler","sequence":"additional","affiliation":[{"name":"Paediatric Dermatology Great Ormond St Hospital for Children  London UK"},{"name":"Genetics and Genomic Medicine UCL GOS Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona J.","family":"Frieden","sequence":"additional","affiliation":[{"name":"University of California  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,14]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"261","article-title":"Dominant negative and loss of function mutations of the c\u2010kit (mast\/stem cell growth factor receptor) proto\u2010oncogene in human piebaldism","volume":"50","author":"Spritz RA","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01583.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.014"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700639"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.96722"},{"key":"e_1_2_4_7_1","unstructured":"CunliffeT.Piebaldism. Primary Care Dermatology Society.http:\/\/www.pcds.org.uk\/clinical-guidance\/piebaldism1. Published May 5 2016. Updated November 20 2017. 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