{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:00:34Z","timestamp":1764133234680,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010involuting congenital hemangiomas (<jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content>) are fully formed vascular tumors at birth, with a distinctive clinical, radiologic, and histopathological profile, and classically lack expansion or involution over time. We describe a series of <jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content> cases with atypical postnatal growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors retrospectively analyzed all <jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content> cases diagnosed from 2007 to 2017. We reviewed charts and photographic databases from our Vascular Anomalies Clinic. We included in the study all <jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content> with an atypical postnatal growth. Clinical data, imaging, and histopathology were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty cases of <jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content> were identified. Nine presented with atypical postnatal growth after a stable period, at ages from 2 to 10\u00a0years (mean: 5.3\u00a0years). Two patients had associated pain; 5 patients showed new red papules on the surface of the lesion; 2 reported bleeding from the papules; and 1 developed a pyogenic granuloma. All patients had Doppler ultrasound and\/or <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> compatible with <jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content>, and a confirmatory biopsy was performed in 4 cases. In treatment, 2 patients received endovascular embolization, and one required further surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010involuting congenital hemangiomas (<jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content>) may develop significant postnatal growth over time (10% in our series), requiring closer follow\u2010up for longer periods. The development of red papules, pyogenic granulomas, and superficial bleeding may be observed. Since this is a small series, we were not able to establish risk factors for <jats:styled-content style=\"fixed-case\">NICH<\/jats:styled-content> with postnatal growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13837","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T11:48:53Z","timestamp":1556624933000},"page":"466-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Non\u2010involuting congenital hemangiomas (<scp>NICH<\/scp>) with postnatal atypical growth: A case series"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0202-3954","authenticated-orcid":false,"given":"Mar\u00eda L.","family":"Cossio","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"},{"name":"Department of Dermatology Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Radiology Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine C.","family":"McCuaig","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-3093","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Coulombe","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Hatami","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Ondrejchak","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Sainte\u2010Justine University Hospital Center University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200106000-00002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.12.1607"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.860"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-1557-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.670"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.010"}],"container-title":["Pediatric 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