{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:53:47Z","timestamp":1767830027616,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric mastocytosis differs from adult mastocytosis in its presentation and clinical course. However, the data regarding the immunophenotypic characterization of mast cells in children are limited. Our objective was to evaluate the immunophenotype of mast cells in pediatric mastocytosis and correlate it with the clinical course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biopsy specimens of children with cutaneous mastocytosis were retrieved from the institutions of pathology and were stained for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>2, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30. The percentage of mast cells and the staining intensity were correlated with the clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five biopsy specimens were included in the study. Patients\u2019 average age was 15.4 at presentation and 37.5 months at biopsy performance. Clinical presentations included maculopapular cutaneous mastocytosis in 79% and mastocytoma in 21% of cases. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>2, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 were positive in 60%, 44%, and 84% of the biopsy specimens, respectively. The staining score was significantly higher for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 as compared to those for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). No correlation was found between the immunophenotype and the clinical form or course of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results confirm that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 is a sensitive marker for pediatric\u2010onset mastocytosis. Nevertheless, its expression does not correlate with clinical subtype or clinical course. The sensitivity of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 is higher than that of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>2 in skin lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13850","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T10:09:51Z","timestamp":1558606191000},"page":"477-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunophenotype of pediatric\u2010onset mastocytosis does not correlate with clinical course"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-2790","authenticated-orcid":false,"given":"Shoshana","family":"Greenberger","sequence":"first","affiliation":[{"name":"Department of Dermatology The Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagai","family":"Landov","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitzhak","family":"Confino","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Dermatology Unit Edith Wolfson Medical Center  Holon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hananya","family":"Vaknine","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Institute of Pathology Edith Wolfson Medical Center  Holon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Avivi","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Institute of Pathology The Chaim Sheba Medical Center  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviv","family":"Barzilai","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Institute of Pathology The Chaim Sheba Medical Center  Ramat Gan 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