{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:56:35Z","timestamp":1777906595635,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>\n                      The development of psoriasis while on tumor necrosis factor inhibitors (\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i) is a paradoxical effect of agents that treat psoriasis. There is a paucity of data available on this entity in juvenile idiopathic arthritis (\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      ). Our objectives were to determine the prevalence of\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i\u2010induced psoriasis in patients with\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      at two pediatric centers, and psoriasis response to therapeutic modifications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed retrospective chart review on patients with\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      treated with\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i (adalimumab, etanercept, infliximab) who developed psoriasis.\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i\u2010induced psoriasis was defined as an incident diagnosis of psoriasis after starting a\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i. Patients with personal histories of psoriasis prior to\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i therapy were excluded. Following diagnosis, responses to medication changes were defined based on physician assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine of 166 (5.4%) patients on\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i for\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      were diagnosed with\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i\u2010induced psoriasis. All cases were female. One had a family history of psoriasis. The median age was 10 (range 2\u201016) years. Five (55%) patients experienced scalp psoriasis, including four (44%) with alopecia. Two (22%) patients achieved significant improvement after switching to different classes of biologic agents, while three (33%) patients had significant improvement following discontinuation of biologic therapy. One of five\u00a0patients who switched to a different\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i had complete resolution, while four had worsening symptoms or partial improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings demonstrate the prevalence of\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i\u2010induced psoriasis in\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      at two centers. Though larger studies are needed, our data suggest discontinuation of\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      i or biologic class switching should be considered as treatment strategies in select patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.13859","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:39:45Z","timestamp":1561509585000},"page":"613-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tumor necrosis factor\u2010\u03b1 inhibitor\u2010induced psoriasis in juvenile idiopathic arthritis patients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-1064","authenticated-orcid":false,"given":"Daniel","family":"Groth","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology Goryeb Children's Hospital at Atlantic Health Morristown New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Perez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Goryeb Children's Hospital at Atlantic Health Morristown New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-8713","authenticated-orcid":false,"given":"James R.","family":"Treat","sequence":"additional","affiliation":[{"name":"Section of Dermatology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3289-446X","authenticated-orcid":false,"given":"Leslie","family":"Castelo\u2010Soccio","sequence":"additional","affiliation":[{"name":"Section of Dermatology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Nativ","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Goryeb Children's Hospital at Atlantic Health Morristown New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela F.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivia","family":"Lapidus","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology Hackensack University Medical Center Hackensack Meridian Health Hackensack New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa J.","family":"Perman","sequence":"additional","affiliation":[{"name":"Section of Dermatology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087288"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.10.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809010-00001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3763-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.038"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.10.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.2.223"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02466-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09329.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13081"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31828390ba"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f3d9ab"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01521.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01267.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20450"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2008.11.013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.372"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy112"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.049916"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8262-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.07.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.10.001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2010.11.001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1218541"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802441234"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.13859","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:01:26Z","timestamp":1694246486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/pde.13859"],"URL":"https:\/\/doi.org\/10.1111\/pde.13859","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736057795.793565570","asserted-by":"object"}]},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]},"assertion":[{"value":"2019-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}