{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:28:26Z","timestamp":1792024106892,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric leukemia cutis (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>) is often difficult to diagnose due to similarity in appearance to other dermatologic diseases. Several case reports and smaller case series have been published in the medical literature, but studies on larger cohorts of children with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to better characterize the clinical features, course, and prognosis of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> in the pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective case series of 31 patients diagnosed with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> at Boston Children's Hospital and the Children's Hospital of Philadelphia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number and morphology of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> lesions varied among patients, with the head and lower extremities being the most common sites of involvement. Leukemia cutis presented concomitantly with systemic leukemia in the majority of cases. Most cases of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> arose during initial leukemia episodes, rather than with relapsed leukemia. Acute myeloid leukemia was the subtype most frequently associated with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>, followed by acute lymphoblastic leukemia. Diagnosis altered treatment timing and therapeutic decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children most often present concomitantly with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and systemic leukemia. Since the morphology and distribution of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> varies, physicians must maintain a high index of suspicion for this diagnosis, as the presence of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> may change the management of systemic leukemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13864","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:55:13Z","timestamp":1562313313000},"page":"658-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pediatric leukemia cutis: A case series"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-1952","authenticated-orcid":false,"given":"Elena Corina","family":"Andriescu","sequence":"first","affiliation":[{"name":"McGovern Medical School University of Texas Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-1725","authenticated-orcid":false,"given":"Carrie C.","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Division of Dermatology Departments of Medicine and Pediatrics Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of California, Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal H.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Division of Pediatric Rheumatology Department of Pediatrics University of Calgary Calgary Alberta Canada"},{"name":"Division of Community Pediatrics Department of Pediatrics University of Calgary Calgary Alberta Canada"},{"name":"Dermatology Research Institute Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Degar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aplenc","sequence":"additional","affiliation":[{"name":"Division of Oncology Center for Pediatric Clinical Effectiveness Children's Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinodh","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Yan","sequence":"additional","affiliation":[{"name":"Section of Pediatric Dermatology Children's Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Departments of Pediatrics and Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn 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