{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:25:42Z","timestamp":1760171142135,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Well\u2010known causes of zinc deficiency, also referred to as acrodermatitis enteropathica (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>), include defects in intestinal zinc transporters and inadequate intake, but a rare cause of acquired zinc deficiency discussed here is an iatrogenic nutritional deficiency caused by parenteral nutrition administered without trace elements. While zinc\u2010depleted parenteral nutrition causing dermatosis of acquired zinc deficiency was first reported in the 1990s, it is now again relevant due to a national vitamin and trace element shortage. A high index of suspicion may be necessary to diagnose zinc deficiency, particularly because early clinical findings are nonspecific. We present this case of acquired zinc deficiency in a patient admitted to a pediatric intensive care unit for respiratory distress and atypical pneumonia, who subsequently developed a severe bullous eruption due to iatrogenic zinc deficiency but was treated effectively with enteral and parenteral zinc supplementation, allowing for rapid re\u2010epithelialization of previously denuded skin.<\/jats:p>","DOI":"10.1111\/pde.13865","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T09:02:54Z","timestamp":1558688574000},"page":"520-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Acquired acrodermatitis enteropathica due to zinc\u2010depleted parenteral nutrition"],"prefix":"10.1111","volume":"36","author":[{"given":"Lauren E.","family":"Wiznia","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3166-2870","authenticated-orcid":false,"given":"Suneet","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nooshin","family":"Brinster","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir M.","family":"Al\u2010Qaqaa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth J.","family":"Orlow","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York"},{"name":"Department of Pediatrics New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikash","family":"Oza","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine New York New York"},{"name":"Department of Pediatrics New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/319514"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00200.x"},{"key":"e_1_2_5_4_1","first-page":"1075","article-title":"Serum zinc and copper during long\u2010term total parenteral nutrition","volume":"90","author":"Chen W","year":"1991","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113509282"},{"issue":"1","key":"e_1_2_5_6_1","first-page":"520","article-title":"Bullous lesions in acrodermatitis enteropathica delaying diagnosis of zinc deficiency: a report of two cases and review of the literature","volume":"35","author":"Jensen SL","year":"2008","journal-title":"J Cutan Pathol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.015"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01491.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612444538"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112463942"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.1.e10"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370115"},{"key":"e_1_2_5_13_1","first-page":"35","article-title":"Zinc deficiency\u2010associated dermatitis in infants during a nationwide shortage of injectable zinc\u2014Washington, DC, and Houston, Texas, 2012\u20102013","volume":"63","author":"Ruktanonchai D","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4154"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.13865","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:24:56Z","timestamp":1694294696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/pde.13865"],"URL":"https:\/\/doi.org\/10.1111\/pde.13865","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2019,5,24]]},"assertion":[{"value":"2019-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}