{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:14:34Z","timestamp":1776539674826,"version":"3.51.2"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01\u2010HS021736"],"award-info":[{"award-number":["R01\u2010HS021736"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01\u2010HS024269"],"award-info":[{"award-number":["R01\u2010HS024269"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p><jats:italic>Staphylococcus aureus<\/jats:italic> is the most prevalent bacterial pathogen in atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) patients presenting with skin infections. Despite the known association between <jats:italic>S\u00a0aureus<\/jats:italic> and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, guidance on empiric antibiotics for skin infections in pediatric <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study over a five\u2010year period to characterize the <jats:italic>S\u00a0aureus<\/jats:italic> strains recovered from pediatric <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients with clinically apparent bacterial skin infections treated in an academic medical center. We assessed patient demographics and dilute bleach bath usage to determine whether these factors were correlated with methicillin resistance. Culture results from our <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> cohort were also compared to those from pediatric patients presenting to the <jats:styled-content style=\"fixed-case\">Saint\u00a0Louis\u00a0Children's\u00a0Hospital<\/jats:styled-content> emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) with <jats:italic>S\u00a0aureus<\/jats:italic> skin abscesses from 2013 to 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Methicillin\u2010sensitive <jats:italic>S\u00a0aureus<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MSSA<\/jats:styled-content>) was more prevalent (77.8%) than methicillin\u2010resistant <jats:italic>S\u00a0aureus<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content>) (22.2%). There was no correlation between <jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content> and age, sex, race, or dilute bleach bath use. In comparison with pediatric patients presenting to the <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AD<\/jats:styled-content> patients had lower rates of <jats:styled-content style=\"fixed-case\">MSSA<\/jats:styled-content> susceptibility to doxycycline and <jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content> susceptibility to trimethoprim\u2010sulfamethoxazole (<jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SMX<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010generation cephalosporins remain appropriate empiric therapy for most pediatric <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients. In patients with a history of <jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content>, empiric doxycycline or <jats:styled-content style=\"fixed-case\">TMP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SMX<\/jats:styled-content> could be considered, given their high <jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content> susceptibility rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13867","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T07:43:07Z","timestamp":1558683787000},"page":"482-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Staphylococcus aureus<\/i> antibiotic susceptibility patterns in pediatric atopic dermatitis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2133-6756","authenticated-orcid":false,"given":"Cristopher C.","family":"Briscoe","sequence":"first","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Reich","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Washington University School of Medicine St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Fritz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Washington University School of Medicine St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-1725","authenticated-orcid":false,"given":"Carrie C.","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Division of Dermatology Departments of Medicine and Pediatrics Washington University School of Medicine St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.251"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09743.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01661.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2217"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01293.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2017.177"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001753"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31814536e0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/600881"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.13867","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:24:25Z","timestamp":1694294665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/pde.13867"],"URL":"https:\/\/doi.org\/10.1111\/pde.13867","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,24]]},"assertion":[{"value":"2019-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}