{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:20:56Z","timestamp":1782750056214,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Anogenital verrucae (<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>) are benign, human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>)\u2013induced tumors of the anogenital skin and mucosa. Medical therapy for <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> in preadolescents has not been well studied. We explore the efficacy and safety profile of sinecatechins 15% ointment and imiquimod 5% cream in the treatment of <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>, alone and in combination therapy with other commonly used medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010institution, retrospective review of children under 12\u00a0years of age with <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> treated with imiquimod 5% cream and sinecatechins 15% ointment was performed. Demographic data, side effects, and outcomes of therapy were recorded for each patient, and overall efficacy was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 patients met inclusion criteria. Responses were seen in 8 out of 9 patients treated with sinecatechins 15% ointment (5 full, 3 partial, and 1 no response) and 9 out of 17 patients treated with imiquimod 5% cream (4 full, 5 partial, and 8 no response). Combination therapy with one or more of the following treatments (podophyllin, cimetidine, candida antigen injection, and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> vaccine) were evaluated, but no combination was objectively superior to the others. No significant difference was found in overall efficacy between sinecatechins and imiquimod. Side effects were mild and limited to irritation and erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both imiquimod 5% cream and sinecatechins 15% ointment are moderately effective in the treatment of <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> in preadolescent children, with a trend toward greater effectiveness of sinecatechins. Combination therapy with other treatments did not significantly increase the effectiveness of topical therapies. Each modality has a tolerable side effect profile with a low risk of serious complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13881","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T01:23:11Z","timestamp":1560475391000},"page":"623-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapy for anogenital verrucae in preadolescent children with topical and systemic treatment"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-3532","authenticated-orcid":false,"given":"Bahir H.","family":"Chamseddin","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnenna G.","family":"Agim","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Jarin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-6205","authenticated-orcid":false,"given":"Adnan","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas"},{"name":"Department of Dermatology New York Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.201756411"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ813"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04493.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1446"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-195412000-00021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12562"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001397"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2003.20516.x"},{"issue":"1","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5070\/D34VW339W4","article-title":"Imiquimod 5 percent cream and the treatment of cutaneous malignancy","volume":"10","author":"Navi D","year":"2004","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_11_1","unstructured":"U.S. Food and Drug Administration2007.Drug Approval Package. 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Available athttps:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2006\/021902s000TOC.cfmAccessed April 13 2019."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13653"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.08.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02441.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09375.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.789"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00568.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.13881","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:01:38Z","timestamp":1694260898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/pde.13881"],"URL":"https:\/\/doi.org\/10.1111\/pde.13881","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"2019-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}