{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:09:31Z","timestamp":1760044171329,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007475","name":"Canadian Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous patterned hypopigmentation's phenotype is highly variable and may be associated with extracutaneous anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated the phenotypic and clinical characteristics of patients with cutaneous patterned hypopigmentation to determine whether certain patterns were more likely to be associated with underlying anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The charts of 106 children with cutaneous patterned hypopigmentation were reviewed retrospectively (2007\u20102018) at Sainte\u2010Justine University Hospital Centre, in Montreal, Canada<jats:bold>.<\/jats:bold> Retrieved information included sex, age at diagnosis, phototype, pattern, and distribution of the cutaneous lesions and the presence of extracutaneous findings. Data were recorded on a software tool which collects and analyzes phenotypic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The predominant types of cutaneous patterned hypopigmentation were along Blaschko's lines in narrow (38.7%) and broad bands (53.8%). Mixed patterns were observed in 22.5% of children. The anterior trunk and posterior trunk were most frequently affected (69% and 56%, respectively). Extracutaneous involvement, especially neurological and developmental, was present in 28.3% of patients and was significantly associated with \u2265\u00a04 involved body sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distribution and types of cutaneous patterned hypopigmentation were not predictive of extracutaneous findings, with the exception of multiple sites involvement and possibly centrofacial location and blocklike lesions. Follow\u2010up until school entry should help identify subtler associated extracutaneous anomalies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13913","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T08:20:41Z","timestamp":1564474841000},"page":"869-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patterned cutaneous hypopigmentation phenotype characterization: A retrospective study in 106 children"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-4766","authenticated-orcid":false,"given":"Eug\u00e9nie","family":"Belzile","sequence":"first","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"McCuaig","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Le Meur","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Social and Preventive Medicine Laval University Quebec City Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-3093","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Coulombe","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Hatami","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Child Health and Human Development Program Research Institute of the McGill University Health Centre Montreal Quebec Canada"},{"name":"Department of Human Genetics, Faculty of Medicine McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1038\/nrg3424"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1186\/s13023-018-0778-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1590\/abd1806-4841.20132015"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1111\/j.1365-2133.2004.06057.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1007\/978-3-642-38765-4"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1016\/j.spen.2015.11.001"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1016\/j.clindermatol.2010.09.012"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1111\/pcmr.12645"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1111\/j.1525-1470.1992.tb00317.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1111\/bjd.13203"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1016\/j.jaad.2014.11.009"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1002\/humu.22347"},{"issue":"1","key":"e_1_2_6_14_1","first-page":"57","article-title":"Studies on melanin XI. 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