{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:36:39Z","timestamp":1789425399396,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Melanonychia striata is common in children of darker\u2010skinned Asian races, while subungual melanoma is extremely rare and it\u00a0is\u00a0difficult to make a diagnosis clinically. However, performing nail unit biopsies in children is particularly challenging and can result in permanent nail dystrophy. The aim of this study was to review the clinical and histologic characteristics of melanonychia striata in pediatric patients of Asian descent to aid in the clinical decision regarding nail biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010two pediatric patients presenting with melanonychia striata involving single or multiple nails at two tertiary pediatric dermatology clinics in Singapore between 2005 and 2015 were reviewed. Clinical and histopathological data were analyzed, including age at onset, age at presentation, location, color, width, presence of Hutchinson's sign, pseudo\u2010Hutchinson's sign, nail dystrophy, length of follow\u2010up, and clinical evolution. Histopathological assessment was performed by three senior dermatopathologists independently for cases that underwent a nail biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No cases of subungual melanoma were detected in our series. Solitary melanonychia of the thumbnail with a single uniform color was the most common presentation. Pseudo\u2010Hutchinson's sign was commonly observed. Consensus in histological diagnosis emerged amongst all three dermatopathologists in only half of the cases biopsied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The occurrence of melanoma in Asian children presenting with melanonychia is extremely rare. We recommend clinical follow\u2010up and anticipatory guidance for these patients and nail unit biopsy only in the presence of high\u2010risk clinical features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13934","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T08:11:58Z","timestamp":1570003918000},"page":"864-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Should we biopsy melanonychia striata in Asian children? A retrospective observational study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3925-6033","authenticated-orcid":false,"given":"WeiXuan","family":"(Colin) Tan","sequence":"first","affiliation":[{"name":"The National Skin Centre Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"The National Skin Centre Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie C.","family":"Seghers","sequence":"additional","affiliation":[{"name":"KK Women's and Children's Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J. A.","family":"Koh","sequence":"additional","affiliation":[{"name":"KK Women's and Children's Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng Geok","family":"(Nicholas) Goh","sequence":"additional","affiliation":[{"name":"The National Skin Centre Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siong See","family":"(Joyce) Lee","sequence":"additional","affiliation":[{"name":"The National Skin Centre Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.039"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70399-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.12.1600"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01481.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22306.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13863"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.043"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2349"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03232.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13991"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.13934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:34:59Z","timestamp":1694255699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,2]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/pde.13934"],"URL":"https:\/\/doi.org\/10.1111\/pde.13934","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,2]]},"assertion":[{"value":"2019-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}