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A comprehensive literature search of English\u2010language citations based on PubMed queries of selected terms was performed, with exclusion if methodology was not discussed, or if studies had 10 or fewer patients. RHL prevalence in pediatrics has been assessed by measures of point and periodic prevalence, though methodologic limitations may under\u2010 or over\u2010estimate the true prevalence of RHL. Studies have been conducted to evaluate therapeutic safety, tolerability, and efficacy of antivirals in the pediatric population. Pediatric RHL point prevalence ranges from 0.72% to 5.2% depending on the population study and the methodologies used. Pediatric RHL carries a significant public health burden and is often implicated in patients with eczema herpeticum, erythema multiforme, reactive infectious mucositis eruptions, and hypersensitivity reactions. There are few studies that evaluate the rates of occurrence of these sequelae associated with pediatric RHL.<\/jats:p>","DOI":"10.1111\/pde.13978","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T12:18:56Z","timestamp":1568031536000},"page":"808-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-9813","authenticated-orcid":false,"given":"Jusleen","family":"Ahluwalia","sequence":"first","affiliation":[{"name":"Division of Pediatric and Adolescent Dermatology Rady Children\u2019s Hospital San Diego California"},{"name":"Departments of Dermatology and Pediatrics, San Diego School of Medicine University of California San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Pediatric and Adolescent Dermatology Rady Children\u2019s Hospital San Diego California"},{"name":"Departments of Dermatology and Pediatrics, San Diego School of Medicine University of California San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Kusari","sequence":"additional","affiliation":[{"name":"Division of Pediatric and Adolescent Dermatology Rady Children\u2019s Hospital San Diego California"},{"name":"Departments of Dermatology and Pediatrics, San Diego School of Medicine University of California San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-0474","authenticated-orcid":false,"given":"Lawrence F.","family":"Eichenfield","sequence":"additional","affiliation":[{"name":"Division of Pediatric and Adolescent Dermatology Rady Children\u2019s Hospital San Diego California"},{"name":"Departments of Dermatology and Pediatrics, San Diego School of Medicine University of California San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.027"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.02.025"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00157.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1991.tb00128.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1990.tb00026.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970201"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(77)90382-6"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(76)90277-2"},{"key":"e_1_2_4_10_1","first-page":"627","article-title":"Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents","volume":"113","author":"Embil JA","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1975.tb00296.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1967.0276"},{"issue":"7","key":"e_1_2_4_13_1","first-page":"4","article-title":"Clinical aspects of recurrent oral herpes simplex virus infection","volume":"23","author":"Glick M","year":"2002","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_4_14_1","first-page":"19","article-title":"Sero\u2010epidemiological and \u2010sociological patterns of herpes simplex virus infection in the world","volume":"69","author":"Nahmias AJ","year":"1990","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323730"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/649212"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.04.065"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182067cee"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2004.0020"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0806"},{"key":"e_1_2_4_21_1","unstructured":"Food and Drug Administration.Recurrent Herpes labialis: Developing drugs for treatment and prevention guidance for industry. 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