{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:10Z","timestamp":1791356830034,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>\n                      It remains uncertain as to whether genital vitiligo of childhood is segmental or a\n                      <jats:italic>forme fruste<\/jats:italic>\n                      of non\u2010segmental disease. This type of vitiligo is sometimes termed figure\u2010of\u2010eight disease due to female predominance and perineal and perianal hypopigmentation or depigmentation around two orifices, the anal and vaginal introitus. The objective of this series was to categorize the features of genital\u2010limited vitiligo of childhood including comorbidities, family history, and long\u2010term course.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>IRB\u2010approved retrospective chart review of vitiligo cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight cases of vitiligo that began in childhood in the genital area were identified, including clinical course and comorbidities. Involvement of the contiguous skin, including inner thighs, buttocks, and scrotum, was noted in all males. In females, only 1 patient had other sites of vitiligo, which was a solitary lesion on the chest. Therapeutic response to topical corticosteroids for perianal skin was seen in five of six children and topical calcineurin inhibitors with or without calcipotriene in four out of four patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Segmental disease limited to the genitalia was more common in females than males, suggesting that perhaps intervention and work\u2010up for comorbid autoimmune diseases may be required for males with genital\u2010limited vitiligo at onset, but may be deferred in females and added if observation of spread is noted. Differentiation from lichen sclerosus et atrophicus may require biopsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.13998","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T07:34:40Z","timestamp":1572852880000},"page":"64-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genital vitiligo in children: Factors associated with generalized, non\u2010segmental vitiligo"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-1824","authenticated-orcid":false,"given":"Jacquelyn R.","family":"Sink","sequence":"first","affiliation":[{"name":"Department of Dermatology New York Medical College\u2010Metropolitan Hospital New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette B.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-014-0098-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70119-4"},{"key":"e_1_2_5_4_1","first-page":"507","article-title":"Topical tacrolimus is more effective for treatment of vitiligo in patients of skin of color","volume":"10","author":"Silverberg JI","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_5_6_1","first-page":"463","article-title":"Thyroid abnormalities in pediatric patients with vitiligo in New York City","volume":"81","author":"Pagovich OE","year":"2008","journal-title":"Cutis"},{"key":"e_1_2_5_7_1","first-page":"329","article-title":"Segmental vitiligo may not be associated with risk of autoimmune thyroiditis","volume":"9","author":"Silverberg N","year":"2011","journal-title":"Skinmed"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90718-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01778.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13399"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03623.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10709.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.102362"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31324"},{"key":"e_1_2_5_15_1","first-page":"248","article-title":"Vitiligo patients seeking depigmentation therapy: a case report and guidelines for psychological screening","volume":"91","author":"Grau C","year":"2013","journal-title":"Cutis"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00511.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00703.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.081"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.13998","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:22:55Z","timestamp":1693347775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/pde.13998"],"URL":"https:\/\/doi.org\/10.1111\/pde.13998","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]},"assertion":[{"value":"2019-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}