{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:26:57Z","timestamp":1793330817119,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isotretinoin is the mainstay treatment in severe acne; however, its musculoskeletal adverse effects such as lower\u2010back pain can be disabling. Herein, we present four cases of isotretinoin\u2010induced sacroiliitis with variable severity. We also present a review of the literature of isotretinoin\u2010induced sacroiliitis. All our cases were male and human leukocyte antigen (HLA)\u2010B27 negative. Sacroiliitis was detected a median of 55 (10\u2010120)\u00a0days after isotretinoin initiation. Two patients were responsive to baseline sulfasalazine and indomethacin treatment, while the other two patients required more intensive treatments: adalimumab in one and methotrexate in the other. We also identified 15 articles describing 33 patients (17 of whom were female) with isotretinoin\u2010induced sacroiliitis. Most of them were responsive to low\u2010to\u2010medium doses of systemic steroids or non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs). Our patients illustrate that severity of isotretinoin\u2010induced sacroiliitis varies from patient to patient.<\/jats:p>","DOI":"10.1111\/pde.14035","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T14:09:41Z","timestamp":1574690981000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Isotretinoin\u2010induced sacroiliitis: Case series of four patients and a systematic review of the literature"],"prefix":"10.1111","volume":"37","author":[{"given":"\u015eerife G\u00fcl","family":"Karada\u011f","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology Kanuni Sultan S\u00fcleyman Research and Training Hospital University of Health Science Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology 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