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We describe the first reported case of severe methemoglobinemia in a healthy adolescent using daily topical dapsone. Although the medication was prescribed for facial use only, the patient reported topical use over her back and chest as well. This case illustrates the potential for significant systemic dapsone absorption even with daily topical dosing and demonstrates the need for clear anticipatory guidance to prevent the potential morbidity and mortality associated with methemoglobinemia from improper topical dapsone use.<\/jats:p>","DOI":"10.1111\/pde.14080","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T07:39:05Z","timestamp":1577345945000},"page":"377-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severe methemoglobinemia due to topical dapsone misuse in a teenage girl"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-4808","authenticated-orcid":false,"given":"Sarah","family":"Yale","sequence":"first","affiliation":[{"name":"Children's Hospital of Wisconsin\/Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-3144","authenticated-orcid":false,"given":"Nicole","family":"Stefanko","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin\/Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin\/Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"McFadden","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin\/Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin\/Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,25]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q139"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2016.1178759"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0242-0"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3186"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1408272"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.14080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:01:04Z","timestamp":1694012464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,25]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/pde.14080"],"URL":"https:\/\/doi.org\/10.1111\/pde.14080","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,25]]},"assertion":[{"value":"2019-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}