{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:31:51Z","timestamp":1777527111268,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital hemangiomas (CHs) are unusual and diverse tumors distinguished from infantile hemangiomas by being largely developed at birth and glucose transporter (GLUT1)\u2010negative. We describe three infants who presented in utero or at birth with segmentally distributed vascular tumors that were GLUT1\u2010negative, had histology compatible with congenital hemangioma, and exhibited spontaneous clinical involution. One of the three patients had high\u2010output cardiac failure and was found to have a mutation in <jats:italic>GNAQ<\/jats:italic> (c.626A&gt;c, p.Gln209Pro); another had high\u2010output cardiac failure, heterotaxy, and transient hematologic abnormalities and was found to have a mutation in <jats:italic>GNA11<\/jats:italic> (c.626_627delinsCC, p.Gln209Pro). In addition to describing a novel segmental pattern of congenital hemangioma variant with genetic correlations, these cases illustrate the utility of targeted genetic testing to elucidate the exact mutation and thus classification of vascular tumors.<\/jats:p>","DOI":"10.1111\/pde.14143","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T09:51:27Z","timestamp":1586253087000},"page":"548-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Segmental congenital hemangiomas: Three cases of a rare entity"],"prefix":"10.1111","volume":"37","author":[{"given":"Robert J.","family":"Smith","sequence":"first","affiliation":[{"name":"Section of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-1683","authenticated-orcid":false,"given":"Denise","family":"Metry","sequence":"additional","affiliation":[{"name":"Department of Dermatology Texas Children's Hospital Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Deardorff","sequence":"additional","affiliation":[{"name":"Division of Genetics Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-6095","authenticated-orcid":false,"given":"Elizabeth","family":"Heller","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katheryn L.","family":"Grand","sequence":"additional","affiliation":[{"name":"Division of Genetics Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ionela","family":"Iacobas","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Vascular Anomalies Center Texas Children's Hospital Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam I.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"},{"name":"Department of Pathology and Laboratory Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"},{"name":"Division of Dermatopathology Department of Dermatology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy L.","family":"Phung","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Children's Hospital and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Lopez\u2010Terrada","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Children's Hospital and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Steicher","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Cahill","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Children's Hospital of Philadelphia Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Low","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-8713","authenticated-orcid":false,"given":"James R.","family":"Treat","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania United 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