{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:29:29Z","timestamp":1791325769446,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004357","name":"Procter and Gamble","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Diaper dermatitis is one of the most frequent skin conditions affecting infants and is associated with elevated skin pH, exposure to urine and feces, and increased fecal protease and lipase activity, resulting in stratum corneum barrier damage and increased risk of infection. The study aim was to determine the impact of two diaper and wipe regimens on newborn infant skin pH and residual enzyme activity after stool cleaning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two diaper and wipe regimens were compared in a randomized, single\u2010blinded crossover study. Regimen A paired an emollient\u2010containing diaper with an acidic, pH\u2010buffered wipe. Regimen B was a non\u2010emollient diaper and wipe with limited buffering capacity. A 3\u2010day washout period preceded each 3\u2010day regimen use period. Skin pH at the perianal\/buttocks interface (PBI), genital region, and undiapered chest control were measured at baseline and day 3. Skin swabs were collected for residual enzyme activity after a stool cleaning event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diapered skin pH at the PBI was similar to undiapered skin after 3\u00a0days of use for Regimen A, while PBI pH for Regimen B was elevated versus control. PBI pH was lower for Regimen A versus Regimen B. After a stool cleaning, PBI skin pH for Regimen A was lower immediately and had lower residual enzyme activity versus Regimen B (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and the pH\u2010lowering effect was sustained up to 60\u00a0minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the use of an emollient\u2010containing diaper with a pH\u2010buffered wipe creates conditions favorable to optimum diapered skin health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14169","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T08:32:09Z","timestamp":1587457929000},"page":"626-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Use of an emollient\u2010containing diaper and pH\u2010buffered wipe regimen restores skin pH and reduces residual enzymatic activity"],"prefix":"10.1111","volume":"37","author":[{"given":"Jennifer","family":"Gustin","sequence":"first","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bohman","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ogle","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Li","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Fadayel","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Narendran","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty O.","family":"Visscher","sequence":"additional","affiliation":[{"name":"James L. Winkle College of Pharmacy University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Carr","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13329"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203040-00004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094670"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489522"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01711.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1986.tb00498.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb00696.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000215593"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050293"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1986.tb00499.x"},{"key":"e_1_2_7_13_1","unstructured":"Huggies health care.https:\/\/www.huggieshealthcare.com\/en\u2010us\/. 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