{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:19:21Z","timestamp":1792063161972,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Different skin manifestations of COVID\u201019 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A retrospective review of 22 children and adolescents with chilblain\u2010like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID\u201019 in Madrid, Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had lesions clinically consistent with chilblains of the toes or feet, with three also having lesions of the fingers. Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and\/or GI symptoms. None had fever. Coagulation tests, hemogram, serum chemistry, and lupus anticoagulant were normal in all patients tested. One out of 16 tested cases had elevated D\u2010dimer results, but without systemic symptoms or other laboratory anomalies. SARS\u2010CoV\u20102 PCR tested in 19 cases was positive in just one case. Skin biopsies obtained in six patients were consistent with chilblains. On follow\u2010up, all cases showed spontaneous marked improvement or complete healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute chilblains were observed during COVID\u201019 pandemic in children and teenagers. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. Etiopathogenesis remains unknown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14215","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T21:19:21Z","timestamp":1589059161000},"page":"406-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Chilblains in children in the setting of COVID\u201019 pandemic"],"prefix":"10.1111","volume":"37","author":[{"given":"David","family":"Andina","sequence":"first","affiliation":[{"name":"Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-8536","authenticated-orcid":false,"given":"Lucero","family":"Noguera\u2010Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid 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